Stotland Naomi E, Lipschitz Lisa S, Caughey Aaron B
Department of Obstetrics, Gynecology, and Reproductive Sciences, Institute for Health Policy Studies, University of California, San Francisco, USA.
Am J Obstet Gynecol. 2002 Nov;187(5):1203-8. doi: 10.1067/mob.2002.127123.
The purpose of this study was to compare four strategies for treating patients with a previous classic cesarean delivery by medical outcomes and quality-adjusted life years.
A decision tree was designed that compared four strategies for a hypothetical cohort of 10,000 women with a previous classic cesarean delivery: (1) delivery at 39 weeks of gestation, (2) delivery at 36 weeks of gestation without amniocentesis, (3) amniocentesis at 36 weeks of gestation with delivery if the fetus was mature and antenatal corticosteroids if the fetus was immature, and (4) weekly amniocentesis starting at 36 weeks of gestation with delivery when mature.
Strategy 2 provided the greatest maternal quality-adjusted life years. Comparing strategy 1 with strategy 2, it was determined that 27 cesarean deliveries must be performed at 36 weeks of gestation with one associated case of respiratory distress syndrome to prevent one case of uterine rupture. Sensitivity analysis revealed that the uterine rupture rate must be below 0.36% for any strategy to surpass strategy 2 (elective cesarean delivery at 36 weeks of gestation without amniocentesis).
A 36-week delivery may be preferable because it provides a lower risk of severe adverse outcomes and higher maternal quality of life.
本研究旨在通过医疗结局和质量调整生命年比较四种治疗有经典剖宫产史患者的策略。
设计了一个决策树,比较针对10000名有经典剖宫产史的假设队列的四种策略:(1)妊娠39周时分娩,(2)妊娠36周时不进行羊膜腔穿刺术分娩,(3)妊娠36周时进行羊膜腔穿刺术,若胎儿成熟则分娩,若胎儿不成熟则使用产前糖皮质激素,(4)从妊娠36周开始每周进行羊膜腔穿刺术,成熟时分娩。
策略2提供了最高的孕产妇质量调整生命年。比较策略1和策略2,确定必须在妊娠36周时进行27次剖宫产,伴有1例呼吸窘迫综合征相关病例,以预防1例子宫破裂。敏感性分析显示,任何策略要超过策略2(妊娠36周时选择性剖宫产且不进行羊膜腔穿刺术),子宫破裂率必须低于0.36%。
妊娠36周分娩可能更可取,因为它严重不良结局风险较低且孕产妇生活质量较高。