Epstein J B, Phillips N, Parry J, Epstein M S, Nevill T, Stevenson-Moore P
Leukemia/Bone Marrow Transplantation Program of British Columbia, Vancouver Hospital and University of British Columbia, Vancouver, BC, Canada.
Bone Marrow Transplant. 2002 Dec;30(11):785-92. doi: 10.1038/sj.bmt.1703716.
Multiple oral complaints develop following high-dose chemo/radiotherapy and hematopoietic cell transplantation (HCT) which can influence quality of life. The purpose of this investigation was to assess quality of life, oral function, taste and smell in a cohort of patients following HCT. A general quality of life survey (the European Organization for Research and Treatment of Cancer (EORTC)) Quality of Life (QOL) questionnaire (QLQ-C30), with an added oral symptom and function scale and assessment of taste and smell was administered to a consecutive series of patients at day 90-100 post HCT. General QOL was impacted by fatigue, affecting physical, social emotional and cognitive function. While oral function scales appeared to be little affected at day 90-100 post HCT, abnormalities of taste were reported. Reports of changes in taste and smell appeared to parallel each other and changes remained at the time of the survey post-HCT. Change in taste appeared to be closely associated with dry mouth. Patients appeared to have difficulty in differentiating sour and bitter, which had been more affected than salt and sweet taste. Females appeared to report greater changes in taste than males. Increased smell sensitivity and taste change resulted in changes in food preparation in some cases, as did reported increase in sensitivity to sour and bitter taste. Acute complications are well known to affect QOL during the early period following HCT, but little assessment of long-term changes in oral QOL and taste has been conducted following transplant. The EORTC QLQ C-30 questionnaire with the oral addendum provides a measure of the quality of life and oral function, and may provide useful outcome measures for assessment of oral care prevention and management in HCT patients.
大剂量化疗/放疗及造血干细胞移植（HCT）后会出现多种口腔问题，这些问题会影响生活质量。本研究的目的是评估一组HCT患者的生活质量、口腔功能、味觉和嗅觉。在HCT后第90 - 100天，对一系列连续的患者进行了一项一般生活质量调查（欧洲癌症研究与治疗组织（EORTC）生活质量（QOL）问卷（QLQ - C30）），并增加了口腔症状和功能量表以及味觉和嗅觉评估。一般生活质量受到疲劳的影响，进而影响身体、社交、情感和认知功能。虽然在HCT后第90 - 100天口腔功能量表似乎受影响较小，但有味觉异常的报告。味觉和嗅觉变化的报告似乎相互平行，且在HCT后的调查时这些变化仍然存在。味觉变化似乎与口干密切相关。患者似乎难以区分酸味和苦味，这两种味道比咸味和甜味受影响更大。女性报告的味觉变化似乎比男性更多。嗅觉敏感性增加和味觉变化在某些情况下导致了食物制备方式的改变，对酸味和苦味敏感度增加的报告也导致了同样的结果。众所周知，急性并发症在HCT后的早期会影响生活质量，但移植后对口腔生活质量和味觉的长期变化评估较少。带有口腔附录的EORTC QLQ C - 30问卷提供了一种生活质量和口腔功能的测量方法，可能为评估HCT患者的口腔护理预防和管理提供有用的结果指标。
