Schwab Martin E
Department of Neuromorphology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, Winterthurerstr. 190, 8057 Zurich, Switzerland.
Prog Brain Res. 2002;137:351-9. doi: 10.1016/s0079-6123(02)37026-2.
In vitro assays have shown that adult CNS tissue, in particular oligodendrocytes and myelin, contains several molecular constituents (Nogo-A/NI-220, MAG, several proteoglycans) which exert neurite growth inhibitory activity. Elimination of oligodendrocytes or myelin, or application of antibodies against some of these constituents enhance regenerative growth and compensatory sprouting of lesioned and unlesioned fiber tracts in spinal cord and brain. Enhanced growth is paralleled by various degrees of functional recovery.
体外试验表明，成体中枢神经系统组织，尤其是少突胶质细胞和髓磷脂，含有几种具有神经突生长抑制活性的分子成分（Nogo-A/NI-220、髓鞘相关糖蛋白、几种蛋白聚糖）。去除少突胶质细胞或髓磷脂，或应用针对其中一些成分的抗体，可增强脊髓和脑中损伤和未损伤纤维束的再生生长和代偿性发芽。生长增强伴随着不同程度的功能恢复。
