Maier Irin C, Ichiyama Ronaldo M, Courtine Grégoire, Schnell Lisa, Lavrov Igor, Edgerton V Reggie, Schwab Martin E
Brain Research Institute, Winterthurerstrasse 190, Zurich, Switzerland.
Brain. 2009 Jun;132(Pt 6):1426-40. doi: 10.1093/brain/awp085. Epub 2009 Apr 16.
Locomotor training on treadmills can improve recovery of stepping in spinal cord injured animals and patients. Likewise, lesioned rats treated with antibodies against the myelin associated neurite growth inhibitory protein, Nogo-A, showed increased regeneration, neuronal reorganization and behavioural improvements. A detailed kinematic analysis showed that the hindlimb kinematic patterns that developed in anti-Nogo-A antibody treated versus treadmill trained spinal cord injured rats were significantly different. The synchronous combined treatment group did not show synergistic effects. This lack of synergistic effects could not be explained by an increase in pain perception, sprouting of calcitonin gene-related peptide (CGRP) positive fibres or by interference of locomotor training with anti-Nogo-A antibody induced regeneration and sprouting of descending fibre tracts. The differential mechanisms leading to behavioural recovery during task-specific training and in regeneration or plasticity enhancing therapies have to be taken into account in designing combinatorial therapies so that their potential positive interactive effects can be fully expressed.
跑步机上的运动训练可改善脊髓损伤动物和患者的步幅恢复。同样，用抗髓磷脂相关神经突生长抑制蛋白Nogo-A的抗体治疗的损伤大鼠，其再生、神经元重组和行为改善均有所增加。详细的运动学分析表明，抗Nogo-A抗体治疗的脊髓损伤大鼠与跑步机训练的脊髓损伤大鼠所形成的后肢运动学模式存在显著差异。同步联合治疗组未显示出协同效应。疼痛感知增加、降钙素基因相关肽（CGRP）阳性纤维的芽生或运动训练对抗Nogo-A抗体诱导的下行纤维束再生和芽生的干扰，均无法解释这种缺乏协同效应的现象。在设计联合疗法时，必须考虑在特定任务训练期间以及再生或可塑性增强疗法中导致行为恢复的不同机制，以便充分发挥其潜在的积极交互作用。
