Bennion L J, Li T K
N Engl J Med. 1976 Jan 1;294(1):9-13. doi: 10.1056/NEJM197601012940103.
To investigate alleged racial differences in alcohol tolerance, we measured the rate of ethanol metabolism in 30 American Indians and 30 whites. The mean rates of alcohol metabolism were virtually identical in the two groups: 92 +/- 3 mg of ethanol metabolized per kilogram of body weight per hour for the Indians versus 93 +/- 3 for the whites (mean +/- S.E.M.). Similarly, a comparison of liver alcohol dehydrogenase specific activity and isoenzyme pattern in biopsy specimens from seven American Indians and six whites revealed no racial differences. Biopsy specimens from the Indians demonstrated a mean specific enzymatic activity of 0.073 +/- 0.004 mumoles of ethanol oxidized per minute per milligram of soluble protein and from the whites, 0.082 +/- 0.009. These findings make it unlikely that alleged racial differences in response to alcohol can be explained on the basis of racial differences in the rate of alcohol metabolism.
为了研究所谓的酒精耐受性种族差异，我们测量了30名美国印第安人和30名白人的乙醇代谢率。两组的酒精代谢平均速率几乎相同：印第安人为每千克体重每小时代谢92±3毫克乙醇，白人为93±3毫克（平均值±标准误）。同样，对7名美国印第安人和6名白人活检标本中的肝脏乙醇脱氢酶比活性和同工酶模式进行比较，未发现种族差异。印第安人的活检标本显示，每毫克可溶性蛋白每分钟氧化乙醇的平均比酶活性为0.073±0.004微摩尔，白人为0.082±0.009。这些发现表明，所谓的对酒精反应的种族差异不太可能基于酒精代谢率的种族差异来解释。
