Narang Upvan, Mainwaring Lawrence, Spath Gina, Barefoot Joe
Closure Medical Corporation, 5250 Greens Dairy Road, Raleigh, NC 27616, USA.
J Cutan Med Surg. 2003 Jan-Feb;7(1):13-9. doi: 10.1007/s10227-002-1155-5. Epub 2002 Nov 27.
In recent years, 2-octyl cyanoacrylate monomer has been formulated for various wound care products that have been approved by the Food and Drug Administration (FDA).
To evaluate the in vitro effectiveness of 2-octyl cyanoacrylate formulation-based films as barriers to various pathogens, including bacteria, fungi, and yeast.
The barrier properties of the cyanoacrylate films prepared by the following two methods were tested: (1) prepolymerized film and (2) in situ polymerized film. The upper surface of films was inoculated such that the microorganisms would have to penetrate the film to colonize the media beneath. Nine different organisms were used. Plates were observed for growth at two, four, and seven days after inoculation.
No growth was observed in any test, with the exception of prepolymerized film challenged with Pseudomonas aeruginosa. The pattern of growth observed suggests that the bacteria colonized the medium by traveling around and not through the film.
2-Octyl cyanoacrylate-based films are excellent microbial barriers.
近年来，2-氰基丙烯酸辛酯单体已被用于多种经美国食品药品监督管理局（FDA）批准的伤口护理产品中。
评估基于2-氰基丙烯酸辛酯配方的薄膜作为对包括细菌、真菌和酵母菌在内的各种病原体的屏障的体外有效性。
测试了通过以下两种方法制备的氰基丙烯酸酯薄膜的屏障性能：（1）预聚合薄膜和（2）原位聚合薄膜。在薄膜的上表面接种，以使微生物必须穿透薄膜才能在下面的培养基上定殖。使用了九种不同的生物体。在接种后两天、四天和七天观察平板上的生长情况。
除了用铜绿假单胞菌挑战的预聚合薄膜外，在任何测试中均未观察到生长。观察到的生长模式表明，细菌是通过在薄膜周围而不是穿过薄膜来在培养基上定殖的。
基于2-氰基丙烯酸辛酯的薄膜是出色的微生物屏障。
