Bertoni Michele, Olivieri Filippo, manghetti Marta, Boccolini Elena, Bellomini Maria Grazia, Blandizzi Corrado, Bonino Ferruccio, Del Tacca Mario
Gastroenterology Unit, University Hospital of Pisa, Pisa, Italy.
Pharmacol Res. 2002 Dec;46(6):525-31. doi: 10.1016/s1043661802002323.
The present study was performed in order to evaluate: (1) the influence of a bicarbonate-alkaline mineral water (Uliveto) on digestive symptoms in patients with functional dyspepsia; (2) the effects of Uliveto on preclinical models of gastric functions. Selected patients complained of dyspeptic symptoms in the absence of digestive lesions or Helicobacter pylori infection within the previous 3 months. They were treated with Uliveto water (1.5 l day(-1)) for 30 days. Frequency and severity of symptoms were assessed at baseline and day 30 by a score system. Preclinical experiments were carried out on rats, allowed to drink Uliveto or oligomineral water for 30 days. Animals then underwent pylorus ligation to evaluate gastric secretion of acid, pepsinogen, and mucus. In separate experiments, gastric emptying was assessed. Crenotherapy was associated with a relief of epigastric pain, retrosternal pyrosis, postprandial fullness and gastric distention. At preclinical level, Uliveto water increased acid and pepsinogen secretions as well as gastric emptying, without changes in bound mucus. The enhancing actions of Uliveto on gastric secretions and emptying were prevented by L-365,260, an antagonist of gastrin/CCK-2 receptors. These findings indicate that a regular intake of Uliveto favors an improvement of dyspeptic symptoms. The preclinical study suggests that the clinical actions of Uliveto water depend mainly on its ability to enhance gastric motor and secretory functions.
(1) 一种碳酸氢盐碱性矿泉水（乌利韦托）对功能性消化不良患者消化症状的影响；(2) 乌利韦托对胃功能临床前模型的作用。入选患者在过去3个月内无消化性病变或幽门螺杆菌感染，但有消化不良症状。他们接受乌利韦托水（1.5升/天）治疗30天。通过评分系统在基线和第30天评估症状的频率和严重程度。在大鼠身上进行临床前实验，让大鼠饮用乌利韦托水或低矿化水30天。然后对动物进行幽门结扎，以评估胃酸、胃蛋白酶原和黏液的分泌。在单独的实验中，评估胃排空情况。矿泉疗法可缓解上腹部疼痛、胸骨后烧灼感、餐后饱胀感和胃扩张。在临床前水平，乌利韦托水增加了胃酸和胃蛋白酶原的分泌以及胃排空，但结合黏液没有变化。胃泌素/CCK-2受体拮抗剂L-365,260可阻止乌利韦托对胃分泌和排空的增强作用。这些发现表明，定期饮用乌利韦托水有助于改善消化不良症状。临床前研究表明，乌利韦托水的临床作用主要取决于其增强胃运动和分泌功能的能力。
