Oumzil H, Ghoulami S, Rhajaoui M, Ilidrissi A, Fkih-Tetouani S, Faid M, Benjouad A
Laboratoire de Biochimie-Immunologie, Département de Biologie, Faculté des Sciences, Rabat, Morocco.
Phytother Res. 2002 Dec;16(8):727-31. doi: 10.1002/ptr.1045.
The essential oils (EO) of Mentha suaveolens, a wild Labiatae, which grows in several regions in Morocco, were characterized and their antimicrobial activity assessed. The main aromatic constituents of this plant, as characterized by IR, NMR and MS studies, were pulegone, piperitenone oxide (PEO) and piperitone oxide (PO) occurring in different amounts depending on the subspecies. These constituents as well as a series of other aromatic products such as carvone, limonene and menthone, were tested for their antimicrobial activity against 19 bacteria including Gram-positive and Gram-negative and against three fungi, using solid phase and microtitration assays. Pulegone-rich essential oil inhibited efficiently all the micro-organisms tested with MICs ranging between 0.69 and 2.77 ppm. Among the components from Mentha suaveolens EO, pulegone was the most effective against the tested microorganisms, followed by PEO and PO. The structure-activity relationship is discussed on the basis of the activity of the other aromatic derivatives tested such as carvone, limonene, menthone and the profile of the essential oils of Mentha suaveolens was compared with other Mentha species.
对生长在摩洛哥多个地区的野生唇形科植物留兰香（Mentha suaveolens）的精油（EO）进行了表征，并评估了其抗菌活性。通过红外光谱（IR）、核磁共振（NMR）和质谱（MS）研究确定，该植物的主要芳香成分是胡薄荷酮、氧化胡椒烯酮（PEO）和氧化胡椒酮（PO），其含量因亚种而异。使用固相和微量滴定法，对这些成分以及一系列其他芳香产物如香芹酮、柠檬烯和薄荷酮，针对19种细菌（包括革兰氏阳性菌和革兰氏阴性菌）和三种真菌进行了抗菌活性测试。富含胡薄荷酮的精油能有效抑制所有测试微生物，其最低抑菌浓度（MIC）在0.69至2.77 ppm之间。在留兰香EO的成分中，胡薄荷酮对测试微生物最有效，其次是PEO和PO。根据所测试的其他芳香衍生物如香芹酮、柠檬烯、薄荷酮的活性，讨论了构效关系，并将留兰香的精油特征与其他薄荷属物种进行了比较。
