葡萄牙薄荷（Mentha cervina）精油的成分与抗真菌活性

Composition and antifungal activity of the essential oil of Mentha cervina from Portugal.

作者信息

Gonçalves M J, Vicente A M, Cavaleiro C, Salgueiro L

机构信息

Laboratório de Farmacognosia/CEF, Faculdade de Farmácia, Universidade de Coimbra, 3000-295 Coimbra, Portugal.

出版信息

Nat Prod Res. 2007 Aug;21(10):867-71. doi: 10.1080/14786410701482244.

DOI:10.1080/14786410701482244

PMID:17680495

Abstract

The chemical composition of the essential oils obtained by hydrodistillation from the aerial parts of Mentha cervina collected during the flowering and vegetative phases of the plants were investigated by GC and GC-MS. Quantitative differences were observed in the compositions, particularly in the amounts of pulegone (12.9-79.6%) and isomenthone (8.7-77.0%). Antifungal activity of the oils was evaluated by minimal inhibitory concentrations (MIC) and minimal lethal concentrations (MLC) against Candida, Apergillus and dermatophyte strains. Antifungal activity of the sample containing lower amounts of pulegone was the highest for dermatophytes, particularly for Epidermophyton floccosum with MIC and MLC values of 0.63 microL mL( - 1). Mentha cervina oils with low content of pulegone, may be an alternative as antifungal agents in dermatophytosis.

摘要

通过水蒸馏法从处于花期和营养期的鹿薄荷地上部分提取挥发油，并采用气相色谱（GC）和气相色谱 - 质谱联用（GC - MS）技术对其化学成分进行了研究。观察到成分存在定量差异，特别是长叶薄荷酮（12.9 - 79.6%）和异薄荷酮（8.7 - 77.0%）的含量。通过最小抑菌浓度（MIC）和最小致死浓度（MLC）评估了这些挥发油对念珠菌、曲霉和皮肤癣菌菌株的抗真菌活性。对于皮肤癣菌，含较低量长叶薄荷酮的样品抗真菌活性最高，尤其是对絮状表皮癣菌，其MIC和MLC值为0.63微升/毫升。含低量长叶薄荷酮的鹿薄荷挥发油可能是皮肤癣菌病抗真菌剂的一种替代品。