Harnafi Hicham, Bouanani Nour El Houda, Aziz Mohammed, Serghini Caid Hana, Ghalim Noreddine, Amrani Souliman
Laboratoire de Biochimie, Faculty of Sciences, Oujda, Morocco.
J Ethnopharmacol. 2007 Jan 3;109(1):156-60. doi: 10.1016/j.jep.2006.09.017. Epub 2006 Sep 24.
In the present study, an aqueous extract from Erica multiflora L. (Ericaceae) flowers was evaluated for its hypocholesterolaemic and hypotriglyceridaemic activities using Triton WR-1339 induced hyperlipemic rats as experimental model. Hyperlipideamia was developed by intraperitonial injection of Triton (200mg/kg body weight). The animals were divided into control (CG), hyperlipidaemic (HG), hyperlipidaemic plus herb extract (HG+EmE) and hyperlipidaemic plus fenofibrate (HG+FF) treated groups. Intragastric administration of Erica multiflora extract (0.25 g/100g body weight) to the rats caused a significant decrease on their plasma lipid levels (quantified using enzymatic kits). At 7h after treatment, plasma total cholesterol, triglycerides and LDL-cholesterol were decreased by 47%, 95% and 67%, respectively, but the change of HDL-cholesterol level was not significant. However, the hypolipidaemic effect of fenofibrate was limited to triglycerides and LDL-cholesterol, which were lowered by about 92% and 41%, respectively. At 24h after treatment, Erica multiflora extract reduced plasma total cholesterol by 68.5% and triglycerides by 91%. HDL-cholesterol was not significantly increased and LDL-cholesterol was lowered by 80.5%. In fenofibrate treated rats, only plasma triglyceride concentrations were lowered by 82%, while the other lipid parameters were not significantly changed indicating that this aqueous herb extract may contain products that lower plasma lipid concentrations and might be beneficial in treatment of hyperlipideamia.
在本研究中，以Triton WR - 1339诱导的高脂血症大鼠为实验模型，评估了多花欧石楠（杜鹃花科）花的水提取物的降胆固醇和降甘油三酯活性。通过腹腔注射Triton（200mg/kg体重）诱导高脂血症。将动物分为对照组（CG）、高脂血症组（HG）、高脂血症加草药提取物组（HG + EmE）和高脂血症加非诺贝特组（HG + FF）。给大鼠灌胃多花欧石楠提取物（0.25 g/100g体重）导致其血浆脂质水平显著降低（使用酶试剂盒进行定量）。治疗后7小时，血浆总胆固醇、甘油三酯和低密度脂蛋白胆固醇分别降低了47%、95%和67%，但高密度脂蛋白胆固醇水平的变化不显著。然而，非诺贝特的降血脂作用仅限于甘油三酯和低密度脂蛋白胆固醇，分别降低了约92%和41%。治疗后24小时，多花欧石楠提取物使血浆总胆固醇降低了68.5%，甘油三酯降低了91%。高密度脂蛋白胆固醇没有显著增加，低密度脂蛋白胆固醇降低了80.5%。在非诺贝特治疗的大鼠中，只有血浆甘油三酯浓度降低了82%，而其他脂质参数没有显著变化，表明这种水性草药提取物可能含有降低血浆脂质浓度的成分，可能对治疗高脂血症有益。
