Rathi S S, Grover J K, Vikrant Vats, Biswas N R
Department of Pharmacology, Dr Rajendra Prasad Center of Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110029, India.
Phytother Res. 2002 Dec;16(8):774-7. doi: 10.1002/ptr.1064.
The efficacy of Momordica charantia (MC), Eugenia jambolana (EJ), Tinospora cordifolia (TC) and Mucuna pruriens (MP) was assessed in the prevention of murine alloxan dibetic cataract. Alloxan (120 mg/kg) was used as the diabetogenic agent. While controls and diabetic controls did not receive any plant extract, treated rats received lyophilized aqueous extract of MC and EJ (200 mg/kg p.o.), alcohol extract of TC (400 mg/kg) and MP (200 mg/kg p.o.) every day until 4 months. Serum glucose concentration was assessed and cataracts examined with both the naked eye and through a slit lamp. Of the eight animals in the diabetic control group, four developed cortical cataract (stage IV) by day 90 while the remaining four developed it by day 100. The incidence rate of cataract in MC, EJ, TC and MP treated groups at 120 days was only 0, 0, 1 and 2. Oral feeding of MC, EJ, TC and MP extracts for 1 month produced a fall of 64.33%, 55.62%, 38.01% and 40.17%, respectively, in the serum glucose levels in comparison with the 48 h level. After 2 months of treatment, the respective values were 66.96%, 59.85%, 40.41% and 45.63%. MC and EJ prevented the development of cataract while the protective effect was less with TC and MP along with a significant reduction of plasma glucose levels (p < 0.001).
评估了苦瓜（MC）、蒲桃（EJ）、心叶青牛胆（TC）和刺毛黧豆（MP）在预防小鼠四氧嘧啶糖尿病性白内障方面的功效。四氧嘧啶（120毫克/千克）用作致糖尿病剂。对照组和糖尿病对照组未接受任何植物提取物，而治疗组大鼠每天接受MC和EJ的冻干水提取物（200毫克/千克，口服）、TC的醇提取物（400毫克/千克）和MP（200毫克/千克，口服），持续4个月。评估血清葡萄糖浓度，并通过肉眼和裂隙灯检查白内障。糖尿病对照组的8只动物中，4只在第90天出现皮质性白内障（IV期），其余4只在第100天出现。MC、EJ、TC和MP治疗组在120天时的白内障发病率分别仅为0、0、1和2。与48小时水平相比，口服MC、EJ、TC和MP提取物1个月后，血清葡萄糖水平分别下降了64.33%、55.62%、38.01%和40.17%。治疗2个月后，相应的值分别为66.96%、59.85%、40.41%和45.63%。MC和EJ可预防白内障的发展，而TC和MP的保护作用较小，同时血浆葡萄糖水平显著降低（p<0.001）。
