Oyelere Sunday Faith, Ajayi Oluwatobi Hezekiah, Ayoade Titilayo Eunice, Santana Pereira George Bueno, Dayo Owoyemi Bolaji Charles, Ilesanmi Ajibola Olaoluwa, Akinyemi Olalekan Amos
Institute of Biomedical Research, Universitat de Lleida, Spain.
Department of Biology, Georgia State University, USA.
Heliyon. 2022 Apr 6;8(4):e09253. doi: 10.1016/j.heliyon.2022.e09253. eCollection 2022 Apr.
Diabetes mellitus is the most well-known endocrine dilemma suffered by hundreds of million people globally, with an annual mortality of more than one million people. This high mortality rate highlights the need for in-depth study of anti-diabetic agents. This review explores the phytochemical contents and anti-diabetic mechanisms of (cucurbitaceae). Studies show that contains several phytochemicals that have hypoglycemic effects, thus, the plant may be effective in the treatment/management of diabetes mellitus. Also, the biochemical and physiological basis of anti-diabetic actions is explained. exhibits its anti-diabetic effects via the suppression of MAPKs and NF-κβin pancreatic cells, promoting glucose and fatty acids catabolism, stimulating fatty acids absorption, inducing insulin production, ameliorating insulin resistance, activating AMPK pathway, and inhibiting glucose metabolism enzymes (fructose-1,6-bisphosphate and glucose-6-phosphatase). Reviewed literature was obtained from credible sources such as PubMed, Scopus, and Web of Science.
糖尿病是全球数亿人所面临的最为人熟知的内分泌难题，每年有超过100万人死亡。这种高死亡率凸显了深入研究抗糖尿病药物的必要性。本综述探讨了（葫芦科）植物的植物化学成分和抗糖尿病机制。研究表明，该植物含有多种具有降血糖作用的植物化学成分，因此，这种植物可能对糖尿病的治疗/管理有效。此外，还解释了该植物抗糖尿病作用的生化和生理基础。该植物通过抑制胰腺细胞中的丝裂原活化蛋白激酶（MAPKs）和核因子κB（NF-κβ）、促进葡萄糖和脂肪酸分解代谢、刺激脂肪酸吸收、诱导胰岛素产生、改善胰岛素抵抗、激活腺苷酸活化蛋白激酶（AMPK）途径以及抑制葡萄糖代谢酶（果糖-1,6-二磷酸酶和葡萄糖-6-磷酸酶）来发挥其抗糖尿病作用。综述文献来自如PubMed、Scopus和科学网等可靠来源。
