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营养基因组学:在营养与健康领域利用系统生物学

Nutrigenomics: exploiting systems biology in the nutrition and health arena.

作者信息

van Ommen Ben, Stierum Rob

机构信息

TNO Nutrition and Food Research, PO Box 360, 3700 AJ Zeist, The Netherlands.

出版信息

Curr Opin Biotechnol. 2002 Oct;13(5):517-21. doi: 10.1016/s0958-1669(02)00349-x.

Abstract

Nutritional sciences are discovering the application of the so-called "omics" sciences. Propelled by the recent unravelling of the human genome and the coinciding technological developments, genotyping, transcriptomics, proteomics and metabolomics are now available to nutritional research. In the future we are likely to see new screening tools for the selection of bioactive nutrients, new biomarkers for the in vivo efficacy of nutrients, and better insight into the influence of genetic polymorphisms on nutrient metabolism. However, are these promises just based on biotechnological hype or is a real fundamental change in human nutritional sciences at hand?

摘要

营养科学正在探索所谓“组学”科学的应用。在人类基因组最近被破解以及同期技术发展的推动下,基因分型、转录组学、蛋白质组学和代谢组学现已应用于营养研究。未来,我们可能会看到用于筛选生物活性营养素的新工具、用于评估营养素体内功效的新生物标志物,以及对基因多态性对营养代谢影响的更深入了解。然而,这些前景仅仅是基于生物技术的炒作,还是人类营养科学即将发生真正的根本性变革呢?

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