Murgia Chiara, Adamski Melissa M
Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, VIC 3168, Australia.
Nutrients. 2017 Apr 6;9(4):366. doi: 10.3390/nu9040366.
Genetics is an important piece of every individual health puzzle. The completion of the Human Genome Project sequence has deeply changed the research of life sciences including nutrition. The analysis of the genome is already part of clinical care in oncology, pharmacology, infectious disease and, rare and undiagnosed diseases. The implications of genetic variations in shaping individual nutritional requirements have been recognised and conclusively proven, yet routine use of genetic information in nutrition and dietetics practice is still far from being implemented. This article sets out the path that needs to be taken to build a framework to translate gene-nutrient interaction studies into best-practice guidelines, providing tools that health professionals can use to understand whether genetic variation affects nutritional requirements in their daily clinical practice.
遗传学是每个人健康谜题的重要组成部分。人类基因组计划序列的完成深刻改变了包括营养科学在内的生命科学研究。基因组分析已成为肿瘤学、药理学、传染病以及罕见和未确诊疾病临床护理的一部分。基因变异在塑造个体营养需求方面的影响已得到认可并得到确凿证明,但在营养与饮食实践中常规使用基因信息仍远未实现。本文阐述了构建一个框架所需采取的路径,该框架可将基因 - 营养素相互作用研究转化为最佳实践指南,并提供工具,使健康专业人员能够在日常临床实践中了解基因变异是否会影响营养需求。