Need J A
Br Med J. 1975 Mar 8;1(5957):548-9. doi: 10.1136/bmj.1.5957.548.
Immunological studies were performed on a woman with severe pre-eclamptic toxaemia in a second pregnancy. This pregnancy followed a normal twin pregnancy by a different father four years earlier. Both fathers were also studied. In the mixed lymphocyte culture the patient's lymphocytes reacted eight times as strongly against father 2's cells as against those from father 1. If studies along these lines are performed when a women has toxaemic and non-toxaemic pregnancies by different fathers information may be obtained on immunogenetic aetiological factors which may be of more value than that derived from the study of large unselected populations.
对一名第二次怀孕患有严重先兆子痫毒血症的妇女进行了免疫学研究。此次怀孕之前四年，她曾与不同的父亲有过一次正常的双胎妊娠。两位父亲也都接受了研究。在混合淋巴细胞培养中，患者的淋巴细胞对父亲2的细胞反应强度是对父亲1细胞反应强度的八倍。如果在一名妇女与不同父亲分别有过毒血症和非毒血症妊娠时进行此类研究，或许可以获取有关免疫遗传学病因因素的信息，这些信息可能比从对大量未经过挑选的人群的研究中获得的信息更有价值。
