不同父亲所孕妊娠中的子痫前期：免疫学研究
Pre-eclampsia in pregnancies by different fathers: immunological studies.
作者信息
Need J A
出版信息
Br Med J. 1975 Mar 8;1(5957):548-9. doi: 10.1136/bmj.1.5957.548.
Abstract
Immunological studies were performed on a woman with severe pre-eclamptic toxaemia in a second pregnancy. This pregnancy followed a normal twin pregnancy by a different father four years earlier. Both fathers were also studied. In the mixed lymphocyte culture the patient's lymphocytes reacted eight times as strongly against father 2's cells as against those from father 1. If studies along these lines are performed when a women has toxaemic and non-toxaemic pregnancies by different fathers information may be obtained on immunogenetic aetiological factors which may be of more value than that derived from the study of large unselected populations.
摘要
对一名第二次怀孕患有严重先兆子痫毒血症的妇女进行了免疫学研究。此次怀孕之前四年，她曾与不同的父亲有过一次正常的双胎妊娠。两位父亲也都接受了研究。在混合淋巴细胞培养中，患者的淋巴细胞对父亲2的细胞反应强度是对父亲1细胞反应强度的八倍。如果在一名妇女与不同父亲分别有过毒血症和非毒血症妊娠时进行此类研究，或许可以获取有关免疫遗传学病因因素的信息，这些信息可能比从对大量未经过挑选的人群的研究中获得的信息更有价值。
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Pre-eclampsia in pregnancies by different fathers: immunological studies.不同父亲所孕妊娠中的子痫前期：免疫学研究
Br Med J. 1975 Mar 8;1(5957):548-9. doi: 10.1136/bmj.1.5957.548.
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本文引用的文献
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Pregnancy toxaemia associated with hydrops foetalis, hydatidiform mole and hydramnios.与胎儿水肿、葡萄胎和羊水过多相关的妊娠毒血症。
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The aetiology, incidence, and heredity of pre-eclamptic toxaemia of pregnancy.妊娠子痫前期毒血症的病因、发病率及遗传因素。
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Serum seromucoid levels in women with previous severe pre-eclampsia or eclampsia.有既往重度子痫前期或子痫病史女性的血清类黏蛋白水平。
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Three closely linked genetic systems relevant to transplantation.与移植相关的三个紧密相连的遗传系统。
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