Birkeland S A, Kristofferson K
Lancet. 1979 Oct 6;2(8145):720-3. doi: 10.1016/s0140-6736(79)90645-7.
Serial lymphocyte counts and function tests were done during and after pre-eclamptic pregnancies, and in the offspring. Compared with normal pregnancies, pre-eclamptic pregnancies were associated with lower B-lymphocyte counts in the fathers; lower T-lymphocyte count, lower B-lymphocyte count, and impaired T-lymphocyte function in mothers; a low response in mixed lymphocyte culture (MLC) tests between the mother and father; and an increased B-cell count in the children. Follow-up of one pre-eclamptic woman throughout pregnancy showed important immune changes at the beginning of the second trimester. These findings suggest that pre-eclampsia is caused by a combination of maternal and paternal hyporesponsiveness together with fetal hyperresponsiveness.
在子痫前期妊娠期间、产后以及子代中进行了系列淋巴细胞计数和功能测试。与正常妊娠相比，子痫前期妊娠的父亲B淋巴细胞计数较低；母亲的T淋巴细胞计数较低、B淋巴细胞计数较低且T淋巴细胞功能受损；母亲和父亲之间的混合淋巴细胞培养（MLC）测试反应较低；子代的B细胞计数增加。对一名子痫前期女性整个孕期的随访显示，在孕中期开始时出现了重要的免疫变化。这些发现表明，子痫前期是由母体和父体低反应性以及胎儿高反应性共同导致的。
