Haltiwanger Robert S
Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, NY 11794-5215, USA.
Curr Opin Struct Biol. 2002 Oct;12(5):593-8. doi: 10.1016/s0959-440x(02)00371-8.
Recent studies from several laboratories have provided evidence that cell surface complex carbohydrates play key roles in the regulation of developmentally relevant signal transduction events. The demonstration that Fringe, a known modifier of Notch function, is a fucose-specific N-acetylglucosaminyltransferase provided strong evidence that the Notch signaling pathway could be regulated by alterations of O-fucose structures. More recently, the demonstration that O-fucose modification of Cripto is essential for Nodal-dependent signaling provides further evidence of a role for glycosylation in signal transduction. These and other examples provide a new paradigm for the regulation of signal transduction events by glycosylation.
来自多个实验室的近期研究提供了证据，表明细胞表面复合碳水化合物在调控与发育相关的信号转导事件中发挥关键作用。已知的Notch功能调节因子Fringe是一种岩藻糖特异性N-乙酰葡糖胺基转移酶，这一发现提供了强有力的证据，表明Notch信号通路可通过O-岩藻糖结构的改变来调节。最近，有证据表明Cripto的O-岩藻糖修饰对于Nodal依赖性信号传导至关重要，这进一步证明了糖基化在信号转导中的作用。这些例子以及其他例子为通过糖基化调节信号转导事件提供了新的范例。
