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海藻酸钙膜与胶原膜用于兔下颌骨缺损引导性骨再生的比较。

Comparison of calcium alginate film with collagen membrane for guided bone regeneration in mandibular defects in rabbits.

作者信息

Jianqi Huang, Hong He, Lieping Sheng, Genghua Gu

机构信息

Received from the Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Medical College, Zhe Jiang University, Hang Zhou, China.

出版信息

J Oral Maxillofac Surg. 2002 Dec;60(12):1449-54. doi: 10.1053/joms.2002.36108.

DOI:10.1053/joms.2002.36108
PMID:12465009
Abstract

PURPOSE

We sought to compare calcium alginate film (CAF) with collagen membrane (CM) regarding their effects on guided bone regeneration.

MATERIALS AND METHODS

Circular bone defects with 5-mm diameter were created in the region anterior to both mandibular angles in 34 rabbits. The defects on one side were covered with a CAF, and the contralateral side with CM. Healing condition was analyzed with gross, radiographic, electromicroscopic, histologic, and immunohistochemical studies and image pattern analysis system after 1, 2, 4, 6, and 8 weeks.

RESULTS

CM absorbed more slowly but collected fewer osteoinductive factors (P <.05) in the early period. CAF induced dense bone formation, whereas CM produced less newly formed bone.

CONCLUSION

CAF is more efficacious than CM in guided bone regeneration in this animal model.

摘要

目的

我们试图比较海藻酸钙膜（CAF）和胶原膜（CM）对引导性骨再生的影响。

材料与方法

在34只兔子双侧下颌角前方区域制造直径5毫米的圆形骨缺损。一侧缺损用CAF覆盖，对侧用CM覆盖。在1、2、4、6和8周后，通过大体观察、影像学、电镜、组织学和免疫组化研究以及图像模式分析系统分析愈合情况。

结果

CM吸收较慢，但在早期收集的骨诱导因子较少（P <.05）。CAF诱导致密骨形成，而CM产生的新形成骨较少。

结论

在该动物模型中，CAF在引导性骨再生方面比CM更有效。

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