Stone Marcus B, Merrick Mark A, Ingersoll Christopher D, Edwards Jeffrey E
Indiana State University, Terre Haute 47809, USA.
Clin J Sport Med. 2002 Nov;12(6):373-8. doi: 10.1097/00042752-200211000-00009.
The purpose of this study was to determine whether a common bromelain regimen or common ibuprofen regimen are effective in resolving pain and muscle dysfunction associated with delayed onset muscle soreness of the elbow flexors.
A randomized, double-blinded, repeated measures design was used for this study.
The study was performed in the Sports Injury Research Lab at an NCAA Division I university.
Forty subjects who had not participated in an upper body resistance-training program 3 months prior to the study, suffered pain or injury in the nondominant arm, or experienced an adverse response to nonsteroidal anti-inflammatory drugs or pineapple (bromelain source) were recruited. Thirty-nine subjects finished the study.
Active range of motion (ROM), perceived pain, and peak concentric torque measurements of the nondominant arm were taken prior to and 24, 48, 72, and 96 hours following an eccentric exercise protocol of the elbow flexors. Subjects were assigned to one of four treatment groups (bromelain 300 mg t.i.d., ibuprofen 400 mg t.i.d., placebo t.i.d., and control) and began treatment immediately following the exercise protocol.
No differences among treatments were observed for any of the dependent variables at any time. ROM deficits and pain peaked between 48 and 72 hours. Peak torque deficiencies were observed between 24 and 72 hours.
Ingestion of bromelain and ibuprofen had no effect on elbow flexor pain, loss of ROM, or loss of concentric peak torque as a result of an eccentric exercise regimen.
本研究旨在确定普通菠萝蛋白酶疗法或普通布洛芬疗法是否能有效缓解与肘屈肌延迟性肌肉酸痛相关的疼痛和肌肉功能障碍。
本研究采用随机、双盲、重复测量设计。
研究在一所美国大学体育协会第一分区大学的运动损伤研究实验室进行。
招募了40名在研究前3个月未参加过上半身抗阻训练计划、非优势手臂有疼痛或损伤、或对非甾体抗炎药或菠萝(菠萝蛋白酶来源)有不良反应的受试者。39名受试者完成了研究。
在进行肘屈肌离心运动方案之前以及之后24、48、72和96小时,对非优势手臂进行主动活动范围(ROM)、疼痛感知和峰值向心扭矩测量。受试者被分配到四个治疗组之一(菠萝蛋白酶300毫克,每日三次;布洛芬400毫克,每日三次;安慰剂,每日三次;以及对照组),并在运动方案后立即开始治疗。
在任何时间,各治疗组之间的任何因变量均未观察到差异。ROM缺陷和疼痛在48至72小时之间达到峰值。峰值扭矩缺陷在24至72小时之间观察到。
摄入菠萝蛋白酶和布洛芬对因离心运动方案导致的肘屈肌疼痛、ROM丧失或向心峰值扭矩丧失没有影响。