Tokmakidis Savvas P, Kokkinidis Efstratios A, Smilios Ilias, Douda Helen
Department of Physical Education & Sport Science, Democritus University of Thrace, Komotini 69100, Greece.
J Strength Cond Res. 2003 Feb;17(1):53-9. doi: 10.1519/1533-4287(2003)017<0053:teoiod>2.0.co;2.
The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance. Nineteen subjects (their mean [+/- SD] age, height, and weight was 24.6 +/- 3.9 years, 176.2 +/- 11.1 cm, 77.3 +/- 18.7 kg) performed the eccentric leg curl exercise to induce muscle soreness in the hamstrings. Nine subjects took an ibuprofen pill of 400 mg every 8 hours within a period of 48 hours, whereas 10 subjects received a placebo randomly (double blind). White blood cells (WBCs) and creatine kinase (CK) were measured at pre-exercise, 4-6, 24, and 48 hours after exercise and maximal strength (1 repetition maximum). Vertical jump performance and knee flexion range of motion (ROM) were measured at pre-exercise, 24 and 48 hours after exercise. Muscle soreness increased (p < 0.05) in both groups after 24 and 48 hours, although the ibuprofen group yielded a significantly lower value (p < 0.05) after 24 hours. The WBC levels were significantly (p < 0.05) increased 4-6 hours postexercise in both groups with no significant difference (p > 0.05) between the 2 groups. The CK values increased (p < 0.05) in the placebo group at 24 and 48 hours postexercise, whereas no significant differences (p > 0.05) were observed in the ibuprofen group. The CK values of the ibuprofen group were lower (p < 0.05) after 48 hours compared with the placebo group. Maximal strength, vertical jump performance, and knee ROM decreased significantly (p < 0.05) after exercise and at 24 and 48 hours postexercise in both the placebo and the ibuprofen groups with no differences being observed (p > 0.05) between the 2 groups. The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.
本研究的目的是探讨布洛芬对延迟性肌肉酸痛（DOMS）、肌肉损伤间接标志物和肌肉性能的影响。19名受试者（平均[±标准差]年龄、身高和体重分别为24.6±3.9岁、176.2±11.1厘米、77.3±18.7千克）进行了离心腿弯举运动，以诱发腘绳肌的肌肉酸痛。9名受试者在48小时内每8小时服用一片400毫克的布洛芬，而10名受试者随机接受安慰剂（双盲）。在运动前、运动后4 - 6小时、24小时和48小时测量白细胞（WBC）和肌酸激酶（CK）以及最大力量（1次重复最大值）。在运动前、运动后24小时和48小时测量垂直跳性能和膝关节屈曲活动范围（ROM）。两组在运动后24小时和48小时肌肉酸痛均增加（p < 0.05），尽管布洛芬组在24小时后的值显著较低（p < 0.05）。两组运动后4 - 6小时白细胞水平均显著升高（p < 0.05），两组之间无显著差异（p > 0.05）。安慰剂组运动后24小时和48小时CK值升高（p < 0.05），而布洛芬组未观察到显著差异（p > 0.05）。与安慰剂组相比，布洛芬组48小时后的CK值较低（p < 0.05）。安慰剂组和布洛芬组运动后以及运动后24小时和48小时最大力量、垂直跳性能和膝关节ROM均显著下降（p < 0.05），两组之间未观察到差异（p > 0.05）。本研究结果表明，摄入布洛芬可减轻离心运动后诱发的肌肉酸痛，但无助于恢复肌肉功能。
