中性粒细胞弹性蛋白酶介导的细菌杀伤作用：来自定向诱变的经验教训。
Neutrophil elastase-mediated killing of bacteria: lessons from targeted mutagenesis.
作者信息
Belaaouaj Abderrazzaq
机构信息
Department of Medicine (Pulmonary Division), Washington University School of Medicine, Barnes-Jewish Hospital, 660 S Euclid Avenue, Campus Box #8052, St Louis MO 63110, USA.
出版信息
Microbes Infect. 2002 Oct;4(12):1259-64. doi: 10.1016/s1286-4579(02)01654-4.
Abstract
Engineering of mice deficient in neutrophil elastase (NE) has allowed us to demonstrate the role of this protease in host defense against bacteria and to begin to understand its killing mechanism. Strategies to inhibit NE because of its involvement in tissue-destructive diseases should be reconsidered, while preserving its beneficial properties.
摘要
对缺乏中性粒细胞弹性蛋白酶（NE）的小鼠进行基因工程改造，使我们能够证明这种蛋白酶在宿主抵抗细菌防御中的作用，并开始了解其杀伤机制。鉴于NE参与组织破坏性疾病，抑制NE的策略应重新考虑，同时保留其有益特性。
Zotero 插件