Hood Donald C, Greenstein Vivienne C, Odel Jeffrey G, Zhang Xian, Ritch Robert, Liebmann Jeffrey M, Hong Jenny E, Chen Candice S, Thienprasiddhi Phamornsak
Department of Psychology, 405 Schermerhorn, Columbia University, New York, NY 10027, USA.
Arch Ophthalmol. 2002 Dec;120(12):1672-81. doi: 10.1001/archopht.120.12.1672.
To determine the relationship between spatially localized multifocal visual evoked potentials (mfVEPs) and Humphrey visual fields (HVFs) in patients with unilateral field defects.
Humphrey visual fields and mfVEPs were obtained from 20 patients with unilateral field losses due to either ischemic optic neuropathy or glaucoma. Monocular mfVEPs were obtained for each eye. The amplitude of the mfVEP responses was calculated using root-mean-square and signal-noise ratio measures. Estimates of the HVF loss in the same regions of the field used for the mfVEP were obtained by interpolating the 24-2 HVF data.
Monocular mfVEP amplitude decreased with HVF loss, although small mfVEP signals were not uniquely associated with poor fields. On average, the monocular mfVEP was indistinguishable from noise for field losses between -5 and -10 dB, and good monocular mfVEP amplitudes were never associated with extensive visual field loss. The interocular ratio of the mfVEP amplitudes correlated well with the difference between the HVF values of the 2 eyes, and this correlation improved with increased signal-noise ratio.
The monocular and interocular results were consistent with a linear relationship between the amplitude of the signal portion of the mfVEP response and linear HVF loss. One way to produce this relationship would be if both the signal in the mfVEP and linear HVF loss were linearly related to the percentage of local ganglion cells lost. The clinical limitations of the mfVEP technique can be understood by taking the signal-noise ratio, and the linear model proposed herein, into consideration.
确定单侧视野缺损患者空间定位多焦点视觉诱发电位（mfVEP）与 Humphrey 视野（HVF）之间的关系。
对 20 例因缺血性视神经病变或青光眼导致单侧视野缺损的患者进行 Humphrey 视野检查和 mfVEP 检测。每只眼睛均进行单眼 mfVEP 检测。使用均方根和信噪比测量方法计算 mfVEP 反应的振幅。通过对 24-2 HVF 数据进行插值，获得用于 mfVEP 的视野相同区域的 HVF 损失估计值。
单眼 mfVEP 振幅随 HVF 损失而降低，尽管小的 mfVEP 信号并非唯一与视野不佳相关。平均而言，对于-5 至-10 dB 的视野损失，单眼 mfVEP 与噪声无法区分，良好的单眼 mfVEP 振幅从未与广泛的视野损失相关。mfVEP 振幅的双眼间比率与双眼 HVF 值之间的差异相关性良好，且随着信噪比增加，这种相关性得到改善。
单眼和双眼结果均与 mfVEP 反应信号部分的振幅与线性 HVF 损失之间的线性关系一致。产生这种关系的一种方式可能是，如果 mfVEP 中的信号和线性 HVF 损失都与局部神经节细胞丢失的百分比呈线性相关。通过考虑信噪比和本文提出的线性模型，可以理解 mfVEP 技术的临床局限性。
