Delacourte André, Sergeant Nicolas, Wattez Annick, Maurage Claude-Alain, Lebert Florence, Pasquier Florence, David Jean-Philippe
Unité Inserm 422, 1, Place de Verdun, 59045 Lille cedex, France.
Exp Gerontol. 2002 Oct-Nov;37(10-11):1291-6. doi: 10.1016/s0531-5565(02)00141-9.
Tauopathy is a concept to describe different genetic or metabolic dysfunctions of tau proteins that generate most of the known dementing disorders. Tauopathy is a degenerating process that also affects the entorhinal formation, and then the hippocampal formation in ageing. In Alzheimer's disease (AD), a disease due to APP dysfunction, a similar tauopathy process in observed in neocortical areas, well correlated to cognitive impairment. One important gap of knowledge is the relationship between tauopathy in the hippocampal formation, ageing, AD, and cognitive impairment. Here we show that the multidisciplinary analysis of numerous brains from non-demented and demented patients suggests the following observations: tauopathy of the hippocampal formation in humans is age-related but not an age-dependent process, also independent of AD, but amplified by APP dysfunctions. Tauopathy in the entorhinal and hippocampal formation could be another type of pathological dysfunction of tau proteins, and a therapeutic target to delay AD. Relevant animal models are desperately needed to address this issue.
tau蛋白病是一个描述tau蛋白不同遗传或代谢功能障碍的概念，这些功能障碍会引发大多数已知的痴呆症。tau蛋白病是一种退行性过程，在衰老过程中也会影响内嗅结构，进而影响海马结构。在阿尔茨海默病（AD）中，一种由淀粉样前体蛋白（APP）功能障碍引起的疾病，在新皮质区域观察到类似的tau蛋白病过程，这与认知障碍密切相关。一个重要的知识空白是海马结构中的tau蛋白病、衰老、AD和认知障碍之间的关系。在这里，我们表明，对来自非痴呆和痴呆患者的大量大脑进行多学科分析得出了以下观察结果：人类海马结构中的tau蛋白病与年龄相关，但不是一个年龄依赖性过程，也独立于AD，但会因APP功能障碍而加剧。内嗅和海马结构中的tau蛋白病可能是tau蛋白的另一种病理功能障碍，也是延缓AD的一个治疗靶点。迫切需要相关的动物模型来解决这个问题。
