Morey Miriam C, Pieper Carl F, Crowley Gail M, Sullivan Robert J, Puglisi Carmel M
Geriatric Research, Education and Clinical Center, Durham, North Carolina, USA.
J Am Geriatr Soc. 2002 Dec;50(12):1929-33. doi: 10.1046/j.1532-5415.2002.50602.x.
To compare mortality of adherents and nonadherents of an exercise program.
Prospective intervention study.
Supervised geriatric fitness program called Gerofit.
One hundred thirty-five adults aged 65 and older who enrolled in Gerofit between January 1, 1990, and November 30, 1999. All participants had a baseline medical screen and exercise test. They were classified as adherent (n = 70) if they participated in Gerofit for more than 47 sessions or nonadherent (n = 65) if they did not complete 47 sessions within the first 6-month period.
Program participation was voluntary and consisted of aerobic, strength, flexibility, and balance exercises. The program met three times week for 90 minutes.
All-cause mortality.
Twenty-six deaths occurred within the 10-year follow-up period. Using proportional hazards, time to death was not related to adherence group. However, in multivariate analyses controlling for age, sex, race, baseline risk/health status, history of heart disease, cancer, diabetes mellitus, and baseline smoking status, there was significant group-by-time interaction (P =.004), indicating a crossover in mortality risk. The initial survival benefit observed in nonadherers changed over time, resulting in a long-term protective survival effect on mortality for the adherent group (hazard rate = 0.75, 95% confidence interval = 0.61-0.91 for the interaction term).
Older adults with chronic diseases experience a long-term beneficial mortality effect from participation in exercise programs. Physicians should strongly encourage their patients, including those with comorbidities, to maintain a regular exercise program.
比较运动计划坚持者与非坚持者的死亡率。
前瞻性干预研究。
一项名为Gerofit的老年健身监督项目。
1990年1月1日至1999年11月30日期间参加Gerofit项目的135名65岁及以上成年人。所有参与者均进行了基线医学筛查和运动测试。如果他们参加Gerofit项目超过47节课程,则被分类为坚持者(n = 70);如果他们在前6个月内未完成47节课程,则被分类为非坚持者(n = 65)。
项目参与是自愿的,包括有氧运动、力量训练、柔韧性训练和平衡训练。该项目每周进行3次,每次90分钟。
全因死亡率。
在10年随访期内发生了26例死亡。使用比例风险模型,死亡时间与坚持组无关。然而,在控制了年龄、性别、种族、基线风险/健康状况、心脏病史、癌症、糖尿病和基线吸烟状况的多变量分析中,存在显著的组间时间交互作用(P = 0.004),表明死亡率风险存在交叉。非坚持者最初观察到的生存益处随时间变化,导致坚持组对死亡率有长期的生存保护作用(交互项的风险比 = 0.75,95%置信区间 = 0.61 - 0.91)。
患有慢性病的老年人参与运动项目可获得长期有益的死亡率效应。医生应强烈鼓励他们的患者,包括那些患有合并症的患者,保持规律的运动计划。