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腰椎退行性脊柱狭窄症的自然病史。

The natural history of lumbar degenerative spinal stenosis.

作者信息

Benoist Michel

机构信息

Orthopedic Surgery Department, Hĵpital Beaujon 92110 Clichy, France.

出版信息

Joint Bone Spine. 2002 Oct;69(5):450-7. doi: 10.1016/s1297-319x(02)00429-3.

DOI:10.1016/s1297-319x(02)00429-3
PMID:12477228
Abstract

The purpose of this review is to present current information on the natural course of lumbar spinal stenosis. As the population becomes older this condition is encountered more frequently. The diagnosis accuracy has improved and the number of cases detected is increasing intemationally. Because of the relative unpredictability of surgical treatment, good knowledge of natural evolution and of the predictive factors influencing the course of the disease is crucial. Unfortunately, and in contrast with numerous surgical series few studies have dealt with natural evolution. In addition to anecdotal reports, a few non randomized studies will be reviewed. Only one randomized study has compared shortand long term results of medical versus surgical treatment. Most of these studies are retrospective, with methodological flaws and are difficult to compare. At the present time no scientifically based recommandations can be made to LSS. patients at diagnosis. Similarly predictors of success of medical and surgical treatment still need to be identified. However results of the studies analyzed in this review suggest that a substantial proportion of patients do not automatically deteriorate and will remain unchanged or even improved by medical means. They also suggest that patients with severe baseline symptoms, block stenosis and degenerative spondylolisthesis tend to require surgical decompression. Randomized studies with the necessary ethical precautions are needed to obtain clear-cut conclusions.

摘要

本综述的目的是介绍腰椎管狭窄自然病程的当前信息。随着人口老龄化,这种疾病的发病率越来越高。诊断准确性有所提高,国际上检测到的病例数量也在增加。由于手术治疗具有相对不可预测性,充分了解疾病的自然演变以及影响病程的预测因素至关重要。遗憾的是,与众多手术系列研究相比,很少有研究涉及自然演变。除了轶事报道外,还将回顾一些非随机研究。只有一项随机研究比较了药物治疗与手术治疗的短期和长期结果。这些研究大多是回顾性的,存在方法学缺陷,难以进行比较。目前,无法针对腰椎管狭窄症患者在诊断时给出基于科学的建议。同样,药物治疗和手术治疗成功的预测因素仍有待确定。然而,本综述分析的研究结果表明,相当一部分患者不会自动恶化,通过药物治疗病情将保持不变甚至改善。研究结果还表明,基线症状严重、存在节段性狭窄和退行性椎体滑脱的患者往往需要手术减压。需要进行具有必要伦理预防措施的随机研究,以得出明确结论。

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