Klempa Boris, Schmidt Heiko A, Ulrich Rainer, Kaluz Stefan, Labuda Milan, Meisel Helga, Hjelle Brian, Krüger Detlev H
Institute of Virology, Charité School of Medicine, Humboldt University, D-10098 Berlin, Germany.
J Virol. 2003 Jan;77(1):804-9. doi: 10.1128/jvi.77.1.804-809.2003.
Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa strains which fell into two distinct genetic lineages. Molecular phylogenetic analyses gave evidence for genetic reassortment between S and M segments of DOBV-Af and DOBV-Aa and indicated homologous recombination events in DOBV evolution. DOBV-Af and DOBV-Aa are distinct but also subject to genetic exchanges that affect their evolutionary trajectories.
多布拉瓦病毒(DOBV)存在于两种不同的啮齿动物物种中,即黄颈姬鼠(DOBV-Af)和黑线姬鼠(DOBV-Aa)。我们对来自同域分布的DOBV-Af和DOBV-Aa毒株的S和M基因组片段进行了测序,这些毒株分为两个不同的遗传谱系。分子系统发育分析为DOBV-Af和DOBV-Aa的S和M片段之间的基因重配提供了证据,并表明在DOBV进化过程中发生了同源重组事件。DOBV-Af和DOBV-Aa是不同的,但也会发生影响其进化轨迹的基因交换。