多布拉瓦汉坦病毒和萨雷马汉坦病毒的血清学差异：两种不同血清型的证据。
Serological divergence of Dobrava and Saaremaa hantaviruses: evidence for two distinct serotypes.
作者信息
Sjölander K B, Golovljova I, Vasilenko V, Plyusnin A, Lundkvist A
机构信息
Swedish Institute for Infectious Disease Control, Stockholm.
出版信息
Epidemiol Infect. 2002 Feb;128(1):99-103. doi: 10.1017/s095026880100632x.
In order to investigate the serological relationship of Dobrava hantavirus (DOBV, originating from Slovenia) and the Dobrava-like Saaremaa virus (SAAV, recently discovered in Estonia) we analysed 37 human serum samples, 24 from Estonia and 13 from the Balkans, by focus reduction neutralization test (FRNT). Most of the Estonian sera (19), including all sera from Saaremaa island (12), reacted with higher FRNT end-point titres to the local SAAV; the majority of them (15 and 11, respectively), with at least fourfold or higher titres to SAAV than to DOBV. In contrast, out of the 13 sera collected in Slovenia, Bosnia-Herzegovina and Greece, only one reacted more strongly with SAAV (with a twofold higher titre), while 10 of these sera reacted more strongly with the local DOBV (9/10 with fourfold or higher titres). These results indicate that DOBV and SAAV define unique hantavirus serotypes.
为了研究多布拉瓦汉坦病毒（DOBV，源自斯洛文尼亚）和类多布拉瓦的萨雷马岛病毒（SAAV，最近在爱沙尼亚发现）之间的血清学关系，我们通过空斑减少中和试验（FRNT）分析了37份人类血清样本，其中24份来自爱沙尼亚，13份来自巴尔干地区。大多数爱沙尼亚血清样本（19份），包括来自萨雷马岛的所有血清样本（12份），对当地的SAAV的FRNT终点滴度更高；其中大多数（分别为15份和11份）对SAAV的滴度比对DOBV的滴度至少高四倍或更高。相比之下，在斯洛文尼亚、波斯尼亚和黑塞哥维那以及希腊采集的13份血清样本中，只有一份对SAAV的反应更强（滴度高两倍），而其中10份血清样本对当地的DOBV反应更强（9/10的滴度高四倍或更高）。这些结果表明，DOBV和SAAV定义了独特的汉坦病毒血清型。
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