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Enhanced inhibition of RNA synthesis by amanitins in in vitro cultured cells.

作者信息

Foá-Tomasi L, Costanzo F, Campadelli-Fiume G

出版信息

Experientia. 1976 Jan 15;32(1):45-6. doi: 10.1007/BF01932615.

DOI:10.1007/BF01932615
PMID:1248586
Abstract

The inhibition of RNA synthesis by alpha-amanitin on in vitro cultured cells is very slow. The action of various analogueoreover pretreatment of cell cultures with DEAE-dextran greatly enhanced the effect of beta-amanitin.

摘要

相似文献

1
Enhanced inhibition of RNA synthesis by amanitins in in vitro cultured cells.
Experientia. 1976 Jan 15;32(1):45-6. doi: 10.1007/BF01932615.
2
Effects of alpha-amanitin on RNA synthesis by mouse embryos in culture.α-鹅膏蕈碱对培养的小鼠胚胎RNA合成的影响。
J Exp Zool. 1978 Mar;203(3):351-60. doi: 10.1002/jez.1402030303.
3
Requirement of host cell RNA polymerase II in the replication of herpes simplex virus in alpha-amanitin-sensitive and -resistant cell lines.
Virology. 1977 Jan;76(1):246-53. doi: 10.1016/0042-6822(77)90300-2.
4
[Effect of transcription inhibitors on RNA synthesis in the polytene chromosomes of Drosophila melanogaster].[转录抑制剂对黑腹果蝇多线染色体中RNA合成的影响]
Tsitologiia. 1988 May;30(5):568-72.
5
Synthesis of low molecular weight RNA components A, C and D by polymerase II in alpha-amanitin-resistant hamster cells.α-鹅膏蕈碱抗性仓鼠细胞中聚合酶II对低分子量RNA组分A、C和D的合成
Nucleic Acids Res. 1979 Jan;6(1):321-30. doi: 10.1093/nar/6.1.321.
6
The differential inhibitory effect of alpha-amanitin on the synthesis of low molecular weight RNA components in BHK cells.α-鹅膏蕈碱对BHK细胞中低分子量RNA组分合成的差异抑制作用。
FEBS Lett. 1978 Mar 15;87(2):227-31. doi: 10.1016/0014-5793(78)80338-x.
7
Stimulation by amphotericin B of uridine transport, RNA synthesis and DNA synthesis in density-inhibited fibroblasts.
Exp Cell Res. 1978 Aug;115(1):37-46. doi: 10.1016/0014-4827(78)90399-3.
8
On the use of alpha-amanitin as a transcriptional blocking agent in mouse embryos: a cautionary note.关于在小鼠胚胎中使用α-鹅膏蕈碱作为转录阻断剂的注意事项。
J Exp Zool. 1985 Jan;233(1):155-9. doi: 10.1002/jez.1402330123.
9
Effects of aphidicolin and alpha-amanitin on visualization of acridine orange binding to DNA in rat astrocytoma C6 cells.阿非科林和α-鹅膏蕈碱对吖啶橙与大鼠星形细胞瘤C6细胞中DNA结合的可视化效果。
Pathol Res Pract. 1985 Mar;179(4-5):499-503.
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Studies on the inhibition by alpha-amanitin of single-step addition reactions and productive RNA synthesis catalysed by wheat-germ RNA polymerase II.α-鹅膏蕈碱对小麦胚芽RNA聚合酶II催化的单步加成反应和有效RNA合成的抑制作用研究。
Biochem J. 1989 Feb 15;258(1):165-9. doi: 10.1042/bj2580165.

引用本文的文献

1
Changes in membrane permeability in cells infected by human cytomegalovirus.
Arch Virol. 1986;89(1-4):203-12. doi: 10.1007/BF01309889.
2
Evidence that herpes simplex virus DNA is transcribed by cellular RNA polymerase B.有证据表明单纯疱疹病毒DNA由细胞RNA聚合酶B转录。
J Virol. 1977 Mar;21(3):996-1001. doi: 10.1128/JVI.21.3.996-1001.1977.
3
Amanitins in virus research.鹅膏毒素在病毒研究中的应用
Arch Virol. 1978;58(1):1-13. doi: 10.1007/BF01315530.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Amanitin binding to calf thymus RNA polymerase B.
FEBS Lett. 1970 Aug 31;9(5):258-260. doi: 10.1016/0014-5793(70)80370-2.
3
Amantis. Chemistry and action.
FEBS Lett. 1970 May 11;8(1):1-5. doi: 10.1016/0014-5793(70)80210-1.
4
Inhibitory effect of naturally occurring and chemically modified amatoxins on RNA polymerase of rat liver nuclei.
天然及化学修饰的鹅膏毒素对大鼠肝细胞核RNA聚合酶的抑制作用。
FEBS Lett. 1971 Apr 12;14(1):42-44. doi: 10.1016/0014-5793(71)80270-3.
5
[Research on the mechanism of cytopathogenic action of alpha-amanitine].[α-鹅膏蕈碱细胞致病作用机制的研究]
Sperimentale. 1966 Jan-Feb;116(1):15-25.
6
Studies on the pathogenesis of liver necrosis by alpha-amanitin. Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei.α-鹅膏蕈碱致肝坏死的发病机制研究。α-鹅膏蕈碱对小鼠肝细胞核核糖核酸合成及核糖核酸聚合酶的影响。
Biochem J. 1967 Nov;105(2):779-82. doi: 10.1042/bj1050779.
7
Impairment of herpesvirus growth in chick embryo fibroblast cultures by -amanitin. Brief report.鹅膏蕈碱对鸡胚成纤维细胞培养物中疱疹病毒生长的损害。简要报告。
Arch Gesamte Virusforsch. 1971;34(4):381-4. doi: 10.1007/BF01242985.
8
Toxicity of and inhibition of RNA polymerase by alpha-amanitin bound to macromolecules by an Azo linkage.通过偶氮键与大分子结合的α-鹅膏蕈碱对RNA聚合酶的毒性及抑制作用。
Hoppe Seylers Z Physiol Chem. 1973 Oct-Nov;354(10-11):1395-8. doi: 10.1515/bchm2.1973.354.2.1395.
9
Inhibition by alpha-amanitin of messenger RNA formation in cultured fibroblasts: potentiation by amphotericin B.α-鹅膏蕈碱对培养成纤维细胞中信使核糖核酸形成的抑制作用：两性霉素B的增强作用。
Exp Cell Res. 1973 Dec;82(2):454-7. doi: 10.1016/0014-4827(73)90365-0.
10
Inhibition of ribonucleic acid and of protein synthesis in the organs of rats and mice poisoned with alpha-amanitin.α-鹅膏蕈碱中毒的大鼠和小鼠器官中核糖核酸和蛋白质合成的抑制作用
Biochim Biophys Acta. 1973 Aug 24;319(2):188-98. doi: 10.1016/0005-2787(73)90009-9.