Kolot F B, Baron S, Yeager H, Schwartz S L
Infect Immun. 1976 Jan;13(1):63-8. doi: 10.1128/iai.13.1.63-68.1976.
Studies were undertaken to compare interferon production among a variety of lymphoreticular cells, with emphasis on the alveolar macrophage. Explanted cells from rabbit lung, spleen, peritoneum, bone marrow, and blood produced interferon in varying amounts in response to six of the seven viruses studied. The various lymphoreticular tissues responded differently to a single interferon-inducing virus, and each tissue produced varying amounts of interferon when stimulated by different viruses. In addition, glass-adherent rabbit alveolar macrophages produced more interferon than did the nonadherent subpopulation. Human blood and lung cells produced much less interferon than did the equivalent rabbit cells under similar conditions of stimulation. It appeared that interferon production may have been controlled by several variables, including the species, the type of inducer, and the type of tissue and cell.
开展了多项研究以比较多种淋巴网状细胞中的干扰素产生情况，重点是肺泡巨噬细胞。从兔肺、脾、腹膜、骨髓和血液中分离出的细胞，对所研究的七种病毒中的六种产生了不同量的干扰素。各种淋巴网状组织对单一干扰素诱导病毒的反应不同，并且每种组织在受到不同病毒刺激时产生的干扰素量也不同。此外，玻璃黏附的兔肺泡巨噬细胞比非黏附亚群产生更多的干扰素。在相似的刺激条件下，人血液和肺细胞产生的干扰素比相应的兔细胞少得多。看来干扰素的产生可能受几个变量的控制，包括物种、诱导剂类型以及组织和细胞类型。
