Fernandez O, Capdevila J Z, Dalla G, Melchor G
Centro Nacional de Sanidad Agropecuaria, Carretera de Jamaica y Autopista Nacional, San José de las Lajas, La Habana, Cuba.
Fitoterapia. 2002 Dec;73(7-8):564-8. doi: 10.1016/s0367-326x(02)00229-0.
Thirty-seven patients with open wounds from surgical intervention of pilonidal cyst (14; 37.8%) or pilonidal fistula (23; 62.2%) were enrolled on a voluntary basis in a comparative blinded clinical trial and randomly assigned to a topical treatment with a Rhizophora mangle aqueous bark extract once a day or twice a day or mercurocrome twice a day. The efficacy of the treatments was evaluated weekly from day 10 to 12 until 6 weeks after surgery by measuring the area of the wounds by image digital planimetry and the tolerability by recording adverse effects. The initial size of the wounds was taken in consideration as covariable in the Generalized Lineal Model used. A thin dark red colored film covering the wound was observed in all the cases treated with the extract. The wound areas of the groups treated with the extract once or twice per day showed a greater reduction (P < 0.05) compared to the group treated with mercurocrome. No differences between the two regimes of application of the extract of R. mangle were observed. No subject showed any sign of adverse effects and no secondary infections were observed.
37例因藏毛囊肿手术干预导致开放性伤口的患者（14例；37.8%）或藏毛窦患者（23例；62.2%）自愿参加一项双盲对照临床试验，并随机分配接受以下治疗：每天一次或每天两次局部使用红树树皮水提取物，或每天两次使用红汞。从术后第10天至12天直至术后6周，每周通过图像数字平面测量法测量伤口面积，并记录不良反应来评估治疗的疗效和耐受性。在使用的广义线性模型中，将伤口的初始大小作为协变量考虑。在用提取物治疗的所有病例中，均观察到伤口上覆盖有一层薄的暗红色薄膜。与使用红汞治疗的组相比，每天使用一次或两次提取物治疗的组伤口面积减小更明显（P<0.05）。未观察到红树提取物两种给药方案之间存在差异。没有受试者出现任何不良反应迹象，也未观察到继发感染。
