Gokhale A B, Damre A S, Saraf M N
Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai 400 098, India.
J Ethnopharmacol. 2003 Jan;84(1):109-14. doi: 10.1016/s0378-8741(02)00168-x.
The objective of the present study was to investigate the immunomodulatory activity of Argyreia speciosa on cellular and humoral immunity. Oral administration of the ethanolic extract of A. speciosa root (ASEE), at the doses of 50, 100 and 200 mg/kg in mice, dose-dependently potentiated the delayed-type hypersensitivity reaction induced both by sheep red blood cells (SRBC) and oxazolone. It significantly enhanced the production of circulating antibody titre in mice in response to SRBC. ASEE failed to show any effect on macrophage phagocytosis. Chronic administration of ASEE significantly ameliorated the total white blood cell count and also restored the myelosuppressive effects induced by cyclophosphamide. The present investigation reveals that ASEE possesses immunomodulatory activity.
本研究的目的是探讨银背藤对细胞免疫和体液免疫的免疫调节活性。给小鼠口服50、100和200mg/kg剂量的银背藤根乙醇提取物（ASEE），剂量依赖性地增强了由绵羊红细胞（SRBC）和恶唑酮诱导的迟发型超敏反应。它显著提高了小鼠对SRBC的循环抗体滴度。ASEE对巨噬细胞吞噬作用未显示任何影响。长期给予ASEE可显著改善白细胞总数，并恢复环磷酰胺诱导的骨髓抑制作用。本研究表明ASEE具有免疫调节活性。
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