Damre A S, Gokhale A B, Phadke A S, Kulkarni K R, Saraf M N
Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai 400 098, India.
Fitoterapia. 2003 Apr;74(3):257-61. doi: 10.1016/s0367-326x(03)00042-x.
The flavonoid fraction of Tephrosia purpurea (FFTP) was studied for its effect on cellular and humoral functions and on macrophage phagocytosis in mice. Oral administration of FFTP (10-40 mg/kg) significantly inhibited sheep red blood cells (SRBC)-induced delayed-type hypersensitivity reactions. It also produced a significant, dose-related decrease in sheep erythrocyte-specific haemagglutination antibody titre. However, the fraction failed to show a significant change in the macrophage phagocytic activity. The results obtained indicate the ability of the flavonoidal fraction of T. purpurea to modulate both the cell-mediated and the humoral components of the immune system.
对紫穗槐黄酮部分（FFTP）进行了研究，以考察其对小鼠细胞和体液功能以及巨噬细胞吞噬作用的影响。口服FFTP（10 - 40毫克/千克）可显著抑制绵羊红细胞（SRBC）诱导的迟发型超敏反应。它还使绵羊红细胞特异性血凝抗体滴度出现显著的、与剂量相关的下降。然而，该部分在巨噬细胞吞噬活性方面未显示出显著变化。所得结果表明紫穗槐黄酮部分具有调节免疫系统细胞介导和体液成分的能力。
