Shukla Shruti, Mehta Archana, John Jinu, Mehta Pradeep, Vyas Suresh Prasad, Shukla Savita
Faculty of Life Sciences, Dr HS Gour Vishwavidyalaya, Sagar 470003, Madhya Pradesh, India.
J Ethnopharmacol. 2009 Sep 7;125(2):252-6. doi: 10.1016/j.jep.2009.07.002. Epub 2009 Jul 14.
Caesalpinia bonducella FLEMING (Caesalpiniaceae) is a plant well known for its medicinal value in Indian Ayurveda. However, to prove its efficiency for the clinical utilization, more experimental data will be beneficial.
The present study involved the investigation of immunomodulatory activities of ethanolic extract of Caesalpinia bonducella seeds.
Neutrophil adhesion test, haemagglutinating antibody (HA) titre, delayed-type hypersensitivity (DTH) response, phagocytic activity and cyclophosphamide-induced myelosuppression were determined by in vivo experiments.
The evaluation of immunomodulatory potential by oral administration of ethanolic seed extract of Caesalpinia bonducella (200-500 mg/kg) evoked a significant increase in percent neutrophil adhesion to nylon fibers as well as a dose-dependent increase in antibody titre values, and potentiated the delayed-type hypersensitivity reaction induced by sheep red blood cells. Also it prevented myelosuppression in cyclophosphamide drug treated rats and good response towards phagocytosis in carbon clearance assay.
The results obtained in this study indicate that Caesalpinia bonducella possesses potential immunomodulatory activity and has therapeutic potential for the prevention of autoimmune diseases.
邦杜克云实（Caesalpinia bonducella FLEMING，豆科云实属）是一种在印度阿育吠陀医学中因其药用价值而闻名的植物。然而，为了证明其临床应用的有效性，更多的实验数据将是有益的。
本研究涉及对邦杜克云实种子乙醇提取物免疫调节活性的研究。
通过体内实验测定中性粒细胞黏附试验、血凝抗体（HA）滴度、迟发型超敏反应（DTH）、吞噬活性和环磷酰胺诱导的骨髓抑制。
口服邦杜克云实种子乙醇提取物（200 - 500 mg/kg）对免疫调节潜力的评估显示，中性粒细胞对尼龙纤维的黏附百分比显著增加，抗体滴度值呈剂量依赖性增加，并增强了绵羊红细胞诱导的迟发型超敏反应。它还预防了环磷酰胺药物治疗大鼠的骨髓抑制，并在碳清除试验中对吞噬作用有良好反应。
本研究获得的结果表明，邦杜克云实具有潜在的免疫调节活性，对预防自身免疫性疾病具有治疗潜力。
