香港耐喹诺酮淋病奈瑟菌的分子特征
Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong.
作者信息
Kam Kai Man, Kam Shirley Sin Yee, Cheung Danny Tze Leung, Tung Viola Wai Na, Au Wai Fun, Cheung May May
机构信息
Sexually Transmitted Diseases Laboratory, Public Health Laboratory Centre, Pathology Service, Department of Health, Kowloon, Hong Kong, China.
出版信息
Antimicrob Agents Chemother. 2003 Jan;47(1):436-9. doi: 10.1128/AAC.47.1.436-439.2003.
Abstract
In Hong Kong, ParC changes among high-level quinolone-resistant Neisseria gonorrhoeae (QRNG) isolates at Ser-87-->Arg were associated with a higher level of resistance than a Ser-87-->Ile alteration. Two previously undescribed mutations in clinical isolates occurring in gyrA, conferring Ala-92-->Pro and Asp-95-->Tyr changes, were detected. Nine different outer membrane lipoprotein (Lip) repeat classes-11 to 19 repeats-were identified, with repeat lengths of 16 and 17 the most common, indicating considerable strain diversity.
摘要
在香港，高水平耐喹诺酮淋病奈瑟菌（QRNG）分离株中，ParC基因第87位丝氨酸（Ser）突变为精氨酸（Arg）与比第87位丝氨酸突变为异亮氨酸（Ile）更高水平的耐药性相关。在临床分离株中检测到gyrA基因发生了两个先前未描述的突变，导致第92位丙氨酸（Ala）变为脯氨酸（Pro）以及第95位天冬氨酸（Asp）变为酪氨酸（Tyr）。鉴定出9种不同的外膜脂蛋白（Lip）重复类别——11至19个重复——其中重复长度为16和17的最为常见，这表明菌株具有相当大的多样性。
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