淋病奈瑟菌环丙沙星耐药菌株parC基因新突变模式的鉴定
Identification of novel mutation patterns in the parC gene of ciprofloxacin-resistant isolates of Neisseria gonorrhoeae.
作者信息
Trees D L, Sandul A L, Whittington W L, Knapp J S
机构信息
Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
出版信息
Antimicrob Agents Chemother. 1998 Aug;42(8):2103-5. doi: 10.1128/AAC.42.8.2103.
Abstract
Of 65 ciprofloxacin-resistant, clinical isolates of Neisseria gonorrhoeae, 5 isolates exhibited ParC mutations previously undescribed in the gonococcus. For isolates containing two ParC mutations (the Ser-87-->Ile and Glu-91-->Gly mutations and the Gly-85-->Cys and Arg116-->Leu mutations) the MICs of ciprofloxacin (8.0 to 64.0 microg/ml) were higher than those for the isolate containing the single ParC mutation (Arg-116-->Leu; MIC, 1.0 microg/ml).
摘要
在65株对环丙沙星耐药的淋病奈瑟菌临床分离株中，有5株表现出淋病奈瑟菌中先前未描述的ParC突变。对于含有两种ParC突变（Ser-87→Ile和Glu-91→Gly突变以及Gly-85→Cys和Arg116→Leu突变）的分离株，环丙沙星的最低抑菌浓度（MICs）（8.0至64.0微克/毫升）高于含有单一ParC突变（Arg-116→Leu；MIC，1.0微克/毫升）的分离株。
相似文献
1
Identification of novel mutation patterns in the parC gene of ciprofloxacin-resistant isolates of Neisseria gonorrhoeae.淋病奈瑟菌环丙沙星耐药菌株parC基因新突变模式的鉴定
Antimicrob Agents Chemother. 1998 Aug;42(8):2103-5. doi: 10.1128/AAC.42.8.2103.
2
Molecular basis of high-level ciprofloxacin resistance in Neisseria gonorrhoeae strains isolated in Denmark from 1995 to 1998.1995年至1998年在丹麦分离出的淋病奈瑟菌菌株中高水平环丙沙星耐药性的分子基础。
Antimicrob Agents Chemother. 2001 Jan;45(1):117-23. doi: 10.1128/AAC.45.1.117-123.2001.
3
Correlation of in vitro susceptibilities to newer quinolones of naturally occurring quinolone-resistant Neisseria gonorrhoeae strains with changes in GyrA and ParC.天然存在的喹诺酮耐药淋病奈瑟菌菌株对新型喹诺酮类药物的体外敏感性与GyrA和ParC变化的相关性
Antimicrob Agents Chemother. 2001 Mar;45(3):734-8. doi: 10.1128/AAC.45.3.734-738.2001.
4
In vitro selection of fluoroquinolone-resistant Neisseria gonorrhoeae harboring alterations in DNA gyrase and topoisomerase IV.体外筛选携带DNA促旋酶和拓扑异构酶IV改变的耐氟喹诺酮淋病奈瑟菌。
J Urol. 2000 Sep;164(3 Pt 1):847-51. doi: 10.1097/00005392-200009010-00060.
5
Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India.来自印度的淋病奈瑟菌环丙沙星耐药菌株中gyrA和parC基因的突变模式。
Sex Transm Infect. 2002 Dec;78(6):440-4. doi: 10.1136/sti.78.6.440.
6
Development of fluoroquinolone resistance and mutations involving GyrA and ParC proteins among Neisseria gonorrhoeae isolates in Japan.日本淋病奈瑟菌分离株中氟喹诺酮耐药性的发展以及涉及GyrA和ParC蛋白的突变
J Urol. 1998 Jun;159(6):2215-9. doi: 10.1016/S0022-5347(01)63308-1.
7
Mutations in the gyrA and parC genes and in vitro activities of fluoroquinolones in 91 clinical isolates of Neisseria gonorrhoeae in Japan.日本91株淋病奈瑟菌临床分离株中gyrA和parC基因的突变及氟喹诺酮类药物的体外活性
Sex Transm Dis. 2004 Mar;31(3):180-4. doi: 10.1097/01.olq.0000114654.91972.66.
8
Characterization of ciprofloxacin resistance in Neisseria gonorrhoeae isolates in Canada.加拿大淋病奈瑟菌分离株中环丙沙星耐药性的特征分析
Sex Transm Dis. 2002 Dec;29(12):780-8. doi: 10.1097/00007435-200212000-00008.
9
Antimicrobial resistance of Neisseria gonorrhoeae and emerging ciprofloxacin resistance in the Netherlands, 1991 to 1998.1991年至1998年荷兰淋病奈瑟菌的抗菌药物耐药性及环丙沙星耐药性的出现
Antimicrob Agents Chemother. 2000 Nov;44(11):3184-5. doi: 10.1128/AAC.44.11.3184-3185.2000.
10
Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates.淋病奈瑟菌在耐氟喹诺酮类药物的分离株中，gyrA和parC的类似区域会发生突变。
Mol Microbiol. 1994 Oct;14(2):371-80. doi: 10.1111/j.1365-2958.1994.tb01297.x.
引用本文的文献
1
Persistence Dynamics of Antimicrobial-Resistant in the Pharynx of Rhesus Macaques.恒河猴咽部抗菌药物耐药性的持续动态变化
Antimicrob Agents Chemother. 2020 Jul 22;64(8). doi: 10.1128/AAC.02232-19.
2
Exploring quinolone resistance-determining region in isolates from across India.探索来自印度各地的 分离株中的喹诺酮耐药决定区。
Indian J Med Res. 2017 Jul;146(Supplement):S64-S69. doi: 10.4103/ijmr.IJMR_730_15.
3
In Vitro Activity of Delafloxacin against Clinical Neisseria gonorrhoeae Isolates and Selection of Gonococcal Delafloxacin Resistance.达氟沙星对临床淋病奈瑟菌分离株的体外活性及淋病奈瑟菌对达氟沙星耐药性的选择
Antimicrob Agents Chemother. 2016 Apr 22;60(5):3106-11. doi: 10.1128/AAC.02798-15. Print 2016 May.
4
An insight into the drug resistance profile & mechanism of drug resistance in Neisseria gonorrhoeae.深入了解淋病奈瑟菌的耐药谱及耐药机制。
Indian J Med Res. 2011 Oct;134(4):419-31.
5
Fluoroquinolone resistance and mutation patterns in gyrA and parC genes in Neisseria gonorrhoeae isolates from Shanghai, China.中国上海淋病奈瑟菌分离株中氟喹诺酮耐药性及gyrA和parC基因的突变模式
J Huazhong Univ Sci Technolog Med Sci. 2009 Feb;29(1):29-34. doi: 10.1007/s11596-009-0106-4. Epub 2009 Feb 18.
6
Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains.临床淋病奈瑟菌菌株耐药性的基因标志物与药敏谱之间的关系。
Antimicrob Agents Chemother. 2008 Jun;52(6):2175-82. doi: 10.1128/AAC.01420-07. Epub 2008 Mar 31.
7
Emergence of fluoroquinolone-resistant Haemophilus influenzae strains among elderly patients but not among children.氟喹诺酮耐药性流感嗜血杆菌菌株在老年患者中出现，但在儿童中未出现。
J Clin Microbiol. 2008 Jan;46(1):361-5. doi: 10.1128/JCM.01561-07. Epub 2007 Oct 31.
8
Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial.莫西沙星对比氧氟沙星加甲硝唑治疗非复杂性盆腔炎：一项多中心、双盲、随机试验的结果
Sex Transm Infect. 2006 Dec;82(6):446-51. doi: 10.1136/sti.2005.019109. Epub 2006 May 24.
9
In vitro assessment of the further potential for development of fluoroquinolone resistance in Neisseria meningitidis.脑膜炎奈瑟菌对氟喹诺酮耐药性进一步发展潜力的体外评估
Antimicrob Agents Chemother. 2005 May;49(5):1753-60. doi: 10.1128/AAC.49.5.1753-1760.2005.
10
Use of applied biosystems 7900HT sequence detection system and Taqman assay for detection of quinolone-resistant Neisseria gonorrhoeae.应用生物系统7900HT序列检测系统和Taqman分析方法检测耐喹诺酮淋病奈瑟菌。
J Clin Microbiol. 2004 Jul;42(7):3281-3. doi: 10.1128/JCM.42.7.3281-3283.2004.
本文引用的文献
1
Rapid screening of point mutations of the Neisseria gonorrhoeae parC gene associated with resistance to quinolones.淋病奈瑟菌parC基因与喹诺酮耐药相关的点突变的快速筛查
J Clin Microbiol. 1997 Apr;35(4):948-50. doi: 10.1128/jcm.35.4.948-950.1997.
2
Fluoroquinolone resistance in Neisseria gonorrhoeae.淋病奈瑟菌对氟喹诺酮类药物的耐药性。
Emerg Infect Dis. 1997 Jan-Mar;3(1):33-9. doi: 10.3201/eid0301.970104.
3
Uncommon occurrence of mutations in the gyrB gene associated with quinolone resistance in clinical isolates of Neisseria gonorrhoeae.淋病奈瑟菌临床分离株中与喹诺酮耐药相关的gyrB基因突变罕见。
Antimicrob Agents Chemother. 1996 Oct;40(10):2437-8. doi: 10.1128/AAC.40.10.2437.
4
Rapid detection of point mutations of the Neisseria gonorrhoeae gyrA gene associated with decreased susceptibilities to quinolones.快速检测与喹诺酮类药物敏感性降低相关的淋病奈瑟菌gyrA基因点突变。
J Clin Microbiol. 1996 Sep;34(9):2255-8. doi: 10.1128/jcm.34.9.2255-2258.1996.
5
Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles.耐喹诺酮淋病奈瑟菌：DNA 回旋酶 GyrA 亚基和拓扑异构酶 IV 的 ParC 亚基改变与抗菌药物敏感性谱的相关性
Antimicrob Agents Chemother. 1996 Apr;40(4):1020-3. doi: 10.1128/AAC.40.4.1020.
6
Proposed criteria for interpretation of susceptibilities of strains of Neisseria gonorrhoeae to ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, and norfloxacin.淋病奈瑟菌菌株对环丙沙星、氧氟沙星、依诺沙星、洛美沙星和诺氟沙星敏感性的解释建议标准。
Antimicrob Agents Chemother. 1995 Nov;39(11):2442-5. doi: 10.1128/AAC.39.11.2442.
7
Antimicrobial susceptibilities of Neisseria gonorrhoeae strains representing five distinct resistance phenotypes.代表五种不同耐药表型的淋病奈瑟菌菌株的抗菌药敏性。
Antimicrob Agents Chemother. 1994 Jan;38(1):155-8. doi: 10.1128/AAC.38.1.155.
8
Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones.金黄色葡萄球菌DNA拓扑异构酶IV的克隆及一级结构：氟喹诺酮类药物的主要作用靶点
Mol Microbiol. 1994 Aug;13(4):641-53. doi: 10.1111/j.1365-2958.1994.tb00458.x.
9
Susceptibility of Neisseria gonorrhoeae associated with pelvic inflammatory disease to cefoxitin, ceftriaxone, clindamycin, gentamicin, doxycycline, azithromycin, and other antimicrobial agents.与盆腔炎相关的淋病奈瑟菌对头孢西丁、头孢曲松、克林霉素、庆大霉素、多西环素、阿奇霉素及其他抗菌药物的敏感性。
Antimicrob Agents Chemother. 1994 Jul;38(7):1688-91. doi: 10.1128/AAC.38.7.1688.
10
Reduced uptake and accumulation of norfloxacin in resistant strains of Neisseria gonorrhoeae isolated in Japan.日本分离出的淋病奈瑟菌耐药菌株中诺氟沙星摄取和积累减少。
Genitourin Med. 1994 Aug;70(4):253-5. doi: 10.1136/sti.70.4.253.
Zotero 插件