Trees D L, Sandul A L, Whittington W L, Knapp J S
Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Antimicrob Agents Chemother. 1998 Aug;42(8):2103-5. doi: 10.1128/AAC.42.8.2103.
Of 65 ciprofloxacin-resistant, clinical isolates of Neisseria gonorrhoeae, 5 isolates exhibited ParC mutations previously undescribed in the gonococcus. For isolates containing two ParC mutations (the Ser-87-->Ile and Glu-91-->Gly mutations and the Gly-85-->Cys and Arg116-->Leu mutations) the MICs of ciprofloxacin (8.0 to 64.0 microg/ml) were higher than those for the isolate containing the single ParC mutation (Arg-116-->Leu; MIC, 1.0 microg/ml).
在65株对环丙沙星耐药的淋病奈瑟菌临床分离株中，有5株表现出淋病奈瑟菌中先前未描述的ParC突变。对于含有两种ParC突变（Ser-87→Ile和Glu-91→Gly突变以及Gly-85→Cys和Arg116→Leu突变）的分离株，环丙沙星的最低抑菌浓度（MICs）（8.0至64.0微克/毫升）高于含有单一ParC突变（Arg-116→Leu；MIC，1.0微克/毫升）的分离株。
