Rissanen Tiina H, Voutilainen Sari, Nyyssönen Kristiina, Salonen Riitta, Kaplan George A, Salonen Jukka T
Research Institute of Public Health, Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland.
Am J Clin Nutr. 2003 Jan;77(1):133-8. doi: 10.1093/ajcn/77.1.133.
Interest in lycopene is growing rapidly following the recent publication of epidemiologic studies in which high circulating lycopene concentrations were associated with reductions in cardiovascular disease. Lycopene is one of the major carotenoids in the Western diet and is probably one of the protective factors in a vegetable-rich diet.
We studied the hypothesis that the intima-media thickness of the common carotid artery (CCA-IMT) would be greater in men with low serum lycopene concentrations.
We investigated the relation between serum lycopene concentration and CCA-IMT in 1028 middle-aged men (aged 46-64 y) in eastern Finland who were participants in the Kuopio Ischaemic Heart Disease Risk Factor study and who were examined in 1991-1993. The subjects were classified into quarters according to serum lycopene concentration.
In a covariance analysis with adjustment for covariates, the men in the lowest quarter of serum lycopene concentration had a significantly higher mean CCA-IMT and maximal CCA-IMT (P = 0.005 and P = 0.001 for the difference, respectively) than did the other men. The mean and maximal CCA-IMT increased linearly across the quarters of serum lycopene concentration.
A low serum lycopene concentration is associated with a higher CCA-IMT in middle-aged men from eastern Finland. This finding suggests that the serum lycopene concentration may play a role in the early stages of atherosclerosis. Increased thickness of the intima-media has been shown to predict coronary events; thus, lycopene intakes and serum concentrations may have clinical and public health relevance.
随着近期流行病学研究的发表，人们对番茄红素的兴趣迅速增长。这些研究表明，血液中番茄红素浓度较高与心血管疾病风险降低相关。番茄红素是西方饮食中的主要类胡萝卜素之一，可能是富含蔬菜饮食中的保护因素之一。
我们研究了这样一个假设，即血清番茄红素浓度低的男性颈总动脉内膜中层厚度（CCA-IMT）会更大。
我们调查了1028名芬兰东部中年男性（年龄46 - 64岁）的血清番茄红素浓度与CCA-IMT之间的关系。这些男性参与了库奥皮奥缺血性心脏病危险因素研究，并于1991 - 1993年接受检查。根据血清番茄红素浓度将受试者分为四组。
在对协变量进行调整的协方差分析中，血清番茄红素浓度最低组的男性平均CCA-IMT和最大CCA-IMT显著高于其他组男性（差异的P值分别为0.005和0.001）。平均和最大CCA-IMT随着血清番茄红素浓度分组呈线性增加。
芬兰东部中年男性血清番茄红素浓度低与较高的CCA-IMT相关。这一发现表明血清番茄红素浓度可能在动脉粥样硬化早期阶段发挥作用。内膜中层厚度增加已被证明可预测冠状动脉事件；因此，番茄红素摄入量和血清浓度可能具有临床和公共卫生意义。
