1Guangdong Provincial Key Laboratory of Food, Nutrition and Health,School of Public Health,Sun Yat-sen University,Guangzhou 510080,People's Republic of China.
2Laboratory Department,Guangdong General Hospital & Guangdong Academy of Medical Sciences,Guangzhou510080,People's Republic of China.
Br J Nutr. 2018 Mar;119(5):590-598. doi: 10.1017/S0007114517003932.
Several studies have suggested that higher carotenoid levels may be beneficial for atherosclerosis patients, but few studies have examined this relationship in the Chinese population. This cross-sectional study examined the association between the levels of carotenoids in diet and serum and carotid intima-media thickness (IMT) in Chinese adults aged 50-75 years in Guangzhou, China. Dietary intake was assessed using a FFQ. HPLC was used to assay the serum concentrations of α-carotene, β-carotene, lutein+zeaxanthin, β-cryptoxanthin and lycopene. The IMT at the common carotid artery (CCA) and bifurcation of the carotid artery was measured by B-mode ultrasound. A total of 3707 and 2947 participants were included in the analyses of dietary and serum carotenoids. After adjustment for demographic, socio-economic and lifestyle factors, all the serum carotenoids levels except lycopene were found to be inversely associated with the IMT at the CCA and bifurcation (P trend<0·001 to 0·013) in both men and women. The absolute mean differences in the IMT between the subjects in the extreme quartiles of serum carotenoid levels were 0·034 mm (α-carotene), 0·037 mm (β-carotene), 0·032 mm (lutein+zeaxanthin), 0·030 mm (β-cryptoxanthin), 0·015 mm (lycopene) and 0·035 mm (total carotenoids) at the CCA; the corresponding values were 0·025, 0·053 0·043, 0·050, 0·011 and 0·042 mm at the bifurcation. The favourable associations were also observed between dietary carotenoids (except lycopene) and the CCA IMT. In conclusion, elevated carotenoid levels in diet and serum are associated with lower carotid IMT values (particular at the CCA) in Chinese adults.
几项研究表明，较高的类胡萝卜素水平可能对动脉粥样硬化患者有益，但很少有研究在中国人群中研究这种关系。这项横断面研究在中国广州，检查了 50-75 岁成年人饮食和血清中类胡萝卜素水平与颈动脉内膜中层厚度（IMT）之间的关系。饮食摄入量使用 FFQ 进行评估。使用 HPLC 测定血清中 α-胡萝卜素、β-胡萝卜素、叶黄素+玉米黄质、β-隐黄质和番茄红素的浓度。通过 B 型超声测量颈总动脉（CCA）和颈总动脉分叉处的 IMT。共纳入 3707 名和 2947 名参与者进行饮食和血清类胡萝卜素分析。在校正人口统计学、社会经济和生活方式因素后，男性和女性的 CCA 和分叉处 IMT 与除番茄红素以外的所有血清类胡萝卜素水平呈负相关（P 趋势<0·001 至 0·013）。血清类胡萝卜素水平处于极端四分位数的受试者之间，CCA 处 IMT 的绝对平均差异为 0·034 毫米（α-胡萝卜素）、0·037 毫米（β-胡萝卜素）、0·032 毫米（叶黄素+玉米黄质）、0·030 毫米（β-隐黄质）、0·015 毫米（番茄红素）和 0·035 毫米（总类胡萝卜素）；相应的值为 0·025、0·053、0·043、0·050、0·011 和 0·042 毫米在分叉处。饮食类胡萝卜素（除番茄红素外）与 CCA IMT 之间也存在有利的关联。总之，饮食和血清中类胡萝卜素水平升高与中国成年人颈动脉 IMT 值降低（尤其是 CCA）有关。
