Zaffe Davide, Bertoldi Carlo, Consolo Ugo
Department of Anatomy and Histology, Section of Human Anatomy, University of Modena and, Reggio Emilia, Italy.
Biomaterials. 2003 Mar;24(6):1093-9. doi: 10.1016/s0142-9612(02)00424-6.
Optical microscopy, scanning electron microscopy and X-ray microanalysis (EDS system) were used on c.p. titanium devices (21 grids and 10 plates) removed from 28 patients without signs of inflammation 6-24 months after surgery. Plates, grids and surrounding tissue were investigated to evaluate the titanium release and accumulation. Titanium was only present in the interfacial bone, probably due to fretting, and in all fibrous tissue surrounding the devices. Titanium content followed a decreasing gradient extending from the device surface and was not detected at a distance greater than 1mm. High titanium levels were found in blood cells in the connective tissue. In conclusion, titanium release from the devices stops only after bone is laid down on the titanium surfaces. Titanium release does not seem to interfere with the osteogenic process but perhaps may interact with it.
对28例患者术后6 - 24个月取出的无炎症迹象的商业纯钛装置（21个网格和10个板）进行了光学显微镜、扫描电子显微镜和X射线微分析（能谱仪系统）。对板、网格和周围组织进行研究以评估钛的释放和积累情况。钛仅存在于界面骨中，可能是由于微动磨损，并且存在于装置周围的所有纤维组织中。钛含量从装置表面开始呈递减梯度，在距离大于1毫米处未检测到。在结缔组织的血细胞中发现了高钛水平。总之，装置中的钛释放仅在钛表面有骨沉积后才停止。钛释放似乎不会干扰成骨过程，但可能与之相互作用。
