Toro Jorge R, Liewehr David J, Pabby Nina, Sorbara Lynn, Raffeld Mark, Steinberg Seth M, Jaffe Elaine S
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7231, USA.
Blood. 2003 May 1;101(9):3407-12. doi: 10.1182/blood-2002-05-1597. Epub 2003 Jan 9.
The importance of alpha beta versus gamma delta T-cell subset antigen expression in the classification of peripheral T-cell lymphomas is still unclear. The objective of this study was to investigate the prognostic value of T-cell receptor-delta 1 (TCR delta 1) expression in primary cutaneous T-cell lymphomas. TCR delta 1 cellular expression was assessed in skin biopsy specimens of 104 individuals with cutaneous T-cell lymphoma by immunohistochemistry. Both univariate (Kaplan-Meier) and multivariate (Cox regression) analyses were conducted to determine which variables (T-cell subtype, hemophagocytosis, histologic profile, age, sex, and adenopathy) were significantly associated with survival. Univariate analysis indicated that there was a statistically significant difference in survival between the patients with alpha beta cutaneous T-cell lymphoma and patients with gamma delta cutaneous T-cell lymphoma (P <.0001). There was also a statistically significant decrease in survival among patients who had subcutaneous involvement compared with patients who had epidermotropic and/or dermal involvement (P <.0001). Cox model analysis indicated that TCR delta 1 expression was the factor that was most closely associated with decreased survival (P <.0001). Among those patients with cutaneous gamma delta T-cell lymphoma (n = 33), there was a trend for decreased survival for patients who had histologic evidence of subcutaneous fat involvement in comparison with patients who had epidermotropic or dermal patterns of infiltration (P =.067). No other prognostic factors were identified as having a notable association with outcome in this subgroup. TCR delta 1 expression in primary cutaneous lymphomas is an independent prognostic factor associated with decreased survival.
αβ与γδ T细胞亚群抗原表达在外周T细胞淋巴瘤分类中的重要性仍不明确。本研究的目的是探讨T细胞受体δ1（TCRδ1）表达在原发性皮肤T细胞淋巴瘤中的预后价值。通过免疫组织化学评估了104例皮肤T细胞淋巴瘤患者皮肤活检标本中的TCRδ1细胞表达。进行单因素（Kaplan-Meier）和多因素（Cox回归）分析以确定哪些变量（T细胞亚型、噬血细胞现象、组织学特征、年龄、性别和淋巴结病）与生存显著相关。单因素分析表明，αβ皮肤T细胞淋巴瘤患者与γδ皮肤T细胞淋巴瘤患者的生存率存在统计学显著差异（P <.0001）。与有亲表皮和/或真皮受累的患者相比，有皮下受累的患者生存率也有统计学显著下降（P <.0001）。Cox模型分析表明，TCRδ1表达是与生存率降低最密切相关的因素（P <.0001）。在那些皮肤γδ T细胞淋巴瘤患者（n = 33）中，与有亲表皮或真皮浸润模式的患者相比，有皮下脂肪受累组织学证据的患者生存率有下降趋势（P =.067）。在该亚组中未发现其他预后因素与结局有显著关联。原发性皮肤淋巴瘤中的TCRδ1表达是与生存率降低相关的独立预后因素。
