[鼠疫耶尔森菌抗原诱导实验动物低氧状态的评估]
[Evaluation of hypoxic state in experimental animals induced by Yersinia pestis antigens].
作者信息
Kagramanov V S, Aseeva L E, Goncharov E K
机构信息
Research Institute for Plague Control, Rostov-on-Don, Russia.
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 2002 Sep-Oct(5):65-7.
Some characteristics of purine metabolism in experimental animals (white mice, clawed jirds and guinea pigs), injected intraperitoneally with Y. pestis "murine" toxin and capsular antigen (Fraction 1), were studied. Under the influence of sublethal doses of these antigens increased levels of guanine and xanthine in blood were noted. Changes in the content of xanthine oxidase in cells were insignificant. In white mice and clawed jirds the activity of succinate dehydrogenase decreased under the action of "murine" toxin and increased after the injection of Fraction 1.
研究了给实验动物（小白鼠、爪哇和豚鼠）腹腔注射鼠疫杆菌“鼠型”毒素和荚膜抗原（组分1）后嘌呤代谢的一些特征。在这些抗原亚致死剂量的影响下，血液中鸟嘌呤和黄嘌呤水平升高。细胞中黄嘌呤氧化酶含量的变化不明显。在小白鼠和爪哇中，“鼠型”毒素作用下琥珀酸脱氢酶的活性降低，注射组分1后活性增加。
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