Kagramanov V S, Aseeva L E, Bursha O S
Zh Mikrobiol Epidemiol Immunobiol. 2010 Nov-Dec(6):61-5.
To study nature of changes in components of glutathione disulfide system of experimental animals influenced by plague "murine" toxin.
Total glutathione level as well as levels of oxidated (G-SS-G) and reduced (GSH) forms of glutathione, activity of glutathione reductase and glutathione peroxidase in erythrocytes of Mongolian gerbils (Meriones unguiculatus), mice and guinea pigs were studied.
Sharp decrease of reduced glutathione level as well as increase of oxidated glutathione level were observed in all experimental animal species after intraperitoneal administration of plague "murine" toxin. Changes in levels of GSH and G-SS-G were followed with decrease of total glutathione level. Activity of glutathione peroxidase was decreased in mice and Mongolian gerbils. There was increase of activity of this enzyme in guinea pigs. Level of glutathione reductase was decreased in all studied animals.
Performed studies allow to hypothesize that oxidation of thiolic functional groups in organisms of animals as a result of H2O2 generation has important role during plague intoxication (administration of sublethal doses of plague "murine" toxin).
研究鼠疫“鼠型”毒素对实验动物谷胱甘肽二硫化物系统各成分变化的影响性质。
研究了长爪沙鼠、小鼠和豚鼠红细胞中总谷胱甘肽水平以及氧化型（G-SS-G）和还原型（GSH）谷胱甘肽水平、谷胱甘肽还原酶和谷胱甘肽过氧化物酶的活性。
所有实验动物腹腔注射鼠疫“鼠型”毒素后，还原型谷胱甘肽水平急剧下降，氧化型谷胱甘肽水平升高。谷胱甘肽和氧化型谷胱甘肽水平的变化伴随着总谷胱甘肽水平的降低。小鼠和长爪沙鼠的谷胱甘肽过氧化物酶活性降低。豚鼠该酶的活性增加。所有研究动物的谷胱甘肽还原酶水平均降低。
所进行的研究使得可以假设，由于过氧化氢的产生，动物机体中硫醇官能团的氧化在鼠疫中毒（给予亚致死剂量的鼠疫“鼠型”毒素）过程中具有重要作用。
