Vignon E, Chapuy M C, Arlot M, Richard M, Louisot P, Vignon G
Pathol Biol (Paris). 1975 Apr;23(4):283-9.
The biochemical composition of cartilage was studied in relation to the site of the sample and the age on 20 normal femoral heads and in relation to the histological appearance of the tissues on 34 arthrosic femoral heads. The collagen and glycosaminoglycan content of normal cartilage is identical in the four poles of the femoral head but becomes reduced with age. The chondroitin sulphate content falls slightly but slowly during ageing. In arthrosis, the glycosaminogylcan content is reduced when the cartilage is eroded and remains roughly normal when the cartilage is macroscopically normal or osteophytic. The cartilage of the osteophyte differs, however, radically from normal articular cartilage by a very high water content and by the presence of glycosaminoglycans which are mainly dialysiable. Similar modifications, that are less marked, occur in the macroscopically normal cartilage of the arthrosic femoral head and suggest the role of a disorder of glycosaminoglycan synthesis in the etiology of certain cases of arthrosis.
对20个正常股骨头的软骨生化成分与样本部位及年龄的关系进行了研究，并对34个患有关节病的股骨头的软骨生化成分与组织学外观的关系进行了研究。正常软骨的胶原蛋白和糖胺聚糖含量在股骨头的四个象限中是相同的，但会随着年龄增长而降低。硫酸软骨素含量在老化过程中略有下降，但下降缓慢。在关节病中，当软骨受到侵蚀时，糖胺聚糖含量会降低，而当软骨在宏观上正常或有骨赘形成时，糖胺聚糖含量大致保持正常。然而，骨赘的软骨与正常关节软骨有根本区别，其含水量非常高，且存在主要可透析的糖胺聚糖。在患有关节病的股骨头的宏观正常软骨中也会出现类似但不太明显的变化，这表明糖胺聚糖合成紊乱在某些关节病病因中起作用。
