Laguens R P, Cossio P M, Diez C, Segal A, Vasquez C, Kreutzer E, Khoury E, Arana R M
Am J Pathol. 1975 Jul;80(1):153-62.
Skeletal muscle biopsies from 21 individuals infected with Trypanosoma cruzi were studied my means of immunofluorescence, ultrastructural immunochemical, light and electron microscopic, and histochemical procedures. In 12 cases, definite morphologic alterations were found. These alterations were coincident with the presence of circulating antibodies against the plasma membrane of striated muscle fibers and endothelial cells (EVI antibodies). In almost all cases the lesions also presented autologous immunoglobulins bound to the plasma membrane of muscle fibers and endothelial cells. Interstitial inflammatory exudate was not observed in the diseased muscle. On the basis of these observations, it is suggested that the EVI antibody is related to some of the pathogenetic mechanism of skeletal muscle damage in Chagas' disease.
对21名感染克氏锥虫的个体进行骨骼肌活检，采用免疫荧光、超微结构免疫化学、光镜和电镜以及组织化学方法进行研究。在12例病例中发现了明确的形态学改变。这些改变与针对横纹肌纤维和内皮细胞质膜的循环抗体（EVI抗体）的存在相一致。在几乎所有病例中，病变还表现为自体免疫球蛋白与肌纤维和内皮细胞质膜结合。在患病肌肉中未观察到间质炎性渗出物。基于这些观察结果，提示EVI抗体与恰加斯病骨骼肌损伤的某些发病机制有关。
