Plewnia Christian, Bartels Mathias, Gerloff Christian
Department of Psychiatry, Neurophysiology Section, University of Tuebingen, Germany.
Ann Neurol. 2003 Feb;53(2):263-6. doi: 10.1002/ana.10468.
It has been proposed that tinnitus is associated with an irregular activation of the temporoparietal cortex. If this activity is a functionally relevant component of the tinnitus-related network, a virtual temporary lesion of this area should result in transient reduction of tinnitus. To test this hypothesis, we applied 10Hz repetitive transcranial magnetic stimulation to eight scalp and four control positions in 14 patients with chronic tinnitus. Stimulation of left temporoparietal cortex significantly reduced tinnitus (Friedman analysis of variance, p < 0.05; compared with control), indicating that secondary auditory areas can be critical for tinnitus perception, perhaps as a consequence of maladaptive cortical reorganization.
有人提出耳鸣与颞顶叶皮质的不规则激活有关。如果这种活动是耳鸣相关网络的功能相关组成部分，那么该区域的虚拟临时损伤应会导致耳鸣暂时减轻。为了验证这一假设，我们对14名慢性耳鸣患者的8个头皮位置和4个对照位置施加了10Hz重复经颅磁刺激。刺激左侧颞顶叶皮质显著减轻了耳鸣（Friedman方差分析，p < 0.05；与对照相比），表明二级听觉区域可能对耳鸣感知至关重要，这可能是适应性不良的皮质重组的结果。
