Casagrande J, Gerkins V, Henderson B E, Mack T, Pike M C
J Natl Cancer Inst. 1976 Apr;56(4):839-41. doi: 10.1093/jnci/56.4.839.
Age, age at menopause, and calendar year at menopause were controlled as factors related to estrogen use. Data on 90 breast cancer patients and 83 conrols--all of whom had a natural menopause--showed no relationship between breast cancer and estrogen usage after the start of menopause symptoms.
年龄、绝经年龄以及绝经时的历年时间作为与雌激素使用相关的因素进行了控制。对90例乳腺癌患者和83例对照者(所有这些人都经历自然绝经)的数据进行分析,结果显示,在出现绝经症状后,乳腺癌与雌激素使用之间不存在关联。