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1
Late events in T4 bacteriophage production. I. Late DNA replication is primarily exponential.T4噬菌体产生过程中的晚期事件。I. 晚期DNA复制主要呈指数增长。
J Virol. 1976 Mar;17(3):794-800. doi: 10.1128/JVI.17.3.794-800.1976.
2
Rescue of DNA replication and bacteriophage production after infection with T4 DNA ligase mutants.用T4 DNA连接酶突变体感染后DNA复制和噬菌体产生的挽救
J Virol. 1973 Feb;11(2):335-7. doi: 10.1128/JVI.11.2.335-337.1973.
3
In vivo production of an RNA-DNA copolymer after infection of Escherichia coli by bacteriophage T4.噬菌体T4感染大肠杆菌后在体内产生RNA-DNA共聚物。
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3165-9. doi: 10.1073/pnas.69.11.3165.
4
T4 and the rolling circle model of replication.T4与滚环复制模型
Annu Rev Genet. 1973;7:325-41. doi: 10.1146/annurev.ge.07.120173.001545.
5
das Mutation in bacteriophage T4D does not suppress an amber mutation in T4 gene 59.噬菌体T4D中的突变不能抑制T4基因59中的琥珀突变。
J Virol. 1975 Nov;16(5):1348-50. doi: 10.1128/JVI.16.5.1348-1350.1975.
6
Late events in T4 bacteriophage production. II. Giant bacteriophages contain concatemers generated by recombination.T4噬菌体产生过程中的晚期事件。II. 巨型噬菌体含有通过重组产生的多联体。
J Virol. 1976 Mar;17(3):801-4. doi: 10.1128/JVI.17.3.801-804.1976.
7
Defective concatemer formation in cells infected with deoxyribonucleic acid-delay mutants of bacteriophage T4.感染噬菌体T4的脱氧核糖核酸延迟突变体的细胞中连接体形成缺陷。
J Virol. 1972 Oct;10(4):858-62. doi: 10.1128/JVI.10.4.858-862.1972.
8
Replication and recombination of gene 59 mutant of bacteriophage T4D.噬菌体T4D基因59突变体的复制与重组
J Virol. 1975 Jan;17(1):175-82. doi: 10.1128/JVI.17.1.175-182.1976.
9
Intracellular inactivation of bacteriophage T4 early deoxyribonucleic acid.噬菌体T4早期脱氧核糖核酸的细胞内失活
J Virol. 1970 May;5(5):659-61. doi: 10.1128/JVI.5.5.659-661.1970.
10
Replication of secondary bacteriophage genomes in heterologous and homologous superinfections.次级噬菌体基因组在异源和同源超感染中的复制。
J Mol Biol. 1966 Jul;18(2):292-307. doi: 10.1016/s0022-2836(66)80247-4.

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1
Anecdotal, historical and critical commentaries on genetics. Gisela Mosig.关于遗传学的轶事、历史及批判性评论。吉塞拉·莫西格。
Genetics. 2004 Nov;168(3):1097-104. doi: 10.1093/genetics/168.3.1097.
2
Late events in T4 bacteriophage DNA replication. III. Specificity of DNA reinitiation as revealed by hybridization to cloned genetic fragments.T4噬菌体DNA复制的后期事件。III. 通过与克隆的基因片段杂交揭示的DNA重新起始的特异性。
J Virol. 1982 May;42(2):422-31. doi: 10.1128/JVI.42.2.422-431.1982.
3
Origins of phage T4 DNA replication as revealed by hybridization to cloned genes.通过与克隆基因杂交揭示的噬菌体T4 DNA复制的起源
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6137-41. doi: 10.1073/pnas.76.12.6137.

本文引用的文献

1
THE DIFFERENCE BETWEEN SPONTANEOUS AND BASE-ANALOGUE INDUCED MUTATIONS OF PHAGE T4.噬菌体T4自发突变与碱基类似物诱导突变之间的差异
Proc Natl Acad Sci U S A. 1959 Apr;45(4):622-33. doi: 10.1073/pnas.45.4.622.
2
REPLICATIVE FRAGMENTATION IN T4 PHAGE: INHIBITION BY CHLORAMPHENICOL.T4噬菌体中的复制性片段化：氯霉素的抑制作用
Proc Natl Acad Sci U S A. 1963 Oct;50(4):746-53. doi: 10.1073/pnas.50.4.746.
3
The frequency distribution of spontaneous bacteriophage mutants as evidence for the exponential rate of phage reproduction.自发噬菌体突变体的频率分布作为噬菌体繁殖指数率的证据。
Cold Spring Harb Symp Quant Biol. 1951;16:463-70. doi: 10.1101/sqb.1951.016.01.033.
4
Fragmentary transfer of P32-labeled parental DNA to progeny phage. II. The average size of the transferred parental fragment. Two-cycletransfer. Repair of the polynucleotide chain after fragmentation.P32标记的亲代DNA向子代噬菌体的片段转移。II. 转移的亲代片段的平均大小。双周期转移。片段化后多核苷酸链的修复。
Virology. 1963 Jun;20:213-29. doi: 10.1016/0042-6822(63)90109-0.
5
Fragmentary transfer of P32-labeled parental DNA to progeny phage.P32标记的亲代DNA向子代噬菌体的片段转移。
Virology. 1961 Jan;13:124-34. doi: 10.1016/0042-6822(61)90039-3.
6
Molecular recombination in T4 bacteriophage deoxyribonucleic acid. I. Tertiary structure of early replicative and recombining deoxyribonucleic acid.T4噬菌体脱氧核糖核酸中的分子重组。I. 早期复制和重组脱氧核糖核酸的三级结构。
J Virol. 1967 Aug;1(4):758-70. doi: 10.1128/JVI.1.4.758-770.1967.
7
Structure of the replicating DNA from bacteriophage T4.来自噬菌体T4的复制DNA的结构
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3049-53. doi: 10.1073/pnas.68.12.3049.
8
DNA replication: the rolling circle model.DNA复制：滚环模型
Cold Spring Harb Symp Quant Biol. 1968;33:473-84. doi: 10.1101/sqb.1968.033.01.055.
9
Replicative hybrid of T4 bacteriophage DNA.T4噬菌体DNA的复制性杂种
J Virol. 1973 Aug;12(2):408-12. doi: 10.1128/JVI.12.2.408-412.1973.
10
T4 and the rolling circle model of replication.T4与滚环复制模型
Annu Rev Genet. 1973;7:325-41. doi: 10.1146/annurev.ge.07.120173.001545.

T4噬菌体产生过程中的晚期事件。I. 晚期DNA复制主要呈指数增长。

Late events in T4 bacteriophage production. I. Late DNA replication is primarily exponential.

作者信息

Kosturko L D, Kozinski A W

出版信息

J Virol. 1976 Mar;17(3):794-800. doi: 10.1128/JVI.17.3.794-800.1976.

DOI:10.1128/JVI.17.3.794-800.1976
PMID:1255858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC515478/
Abstract

The possibility of a switch in the mechanism of T4 DNA replication, from an exponential-bidirectional mode at early stages to a nonexponential (rolling circle) mode at later stages of phage development, has been investigated. The conclusion that DNA replication does not involve such a change in mechanism for the majority of replicating molecules is based on the analysis of the clonal distribution of mutants specifically induced at late times after infection. The clonal distribution of mutants, induced by adding 5-bromodeoxyuridine to infected cells at a time when 100 phage equivalents of DNA had accumulated, fits the pattern predicted by exponential replication.

摘要

已经研究了T4 DNA复制机制发生转变的可能性，即从噬菌体发育早期的指数双向模式转变为后期的非指数（滚环）模式。关于大多数复制分子的DNA复制不涉及这种机制变化的结论，是基于对感染后期特异性诱导的突变体克隆分布的分析得出的。在积累了100个噬菌体当量的DNA时，通过向感染细胞中添加5-溴脱氧尿苷诱导产生的突变体克隆分布，符合指数复制所预测的模式。