T4噬菌体产生过程中的晚期事件。I. 晚期DNA复制主要呈指数增长。
Late events in T4 bacteriophage production. I. Late DNA replication is primarily exponential.
作者信息
Kosturko L D, Kozinski A W
出版信息
J Virol. 1976 Mar;17(3):794-800. doi: 10.1128/JVI.17.3.794-800.1976.
Abstract
The possibility of a switch in the mechanism of T4 DNA replication, from an exponential-bidirectional mode at early stages to a nonexponential (rolling circle) mode at later stages of phage development, has been investigated. The conclusion that DNA replication does not involve such a change in mechanism for the majority of replicating molecules is based on the analysis of the clonal distribution of mutants specifically induced at late times after infection. The clonal distribution of mutants, induced by adding 5-bromodeoxyuridine to infected cells at a time when 100 phage equivalents of DNA had accumulated, fits the pattern predicted by exponential replication.
摘要
已经研究了T4 DNA复制机制发生转变的可能性，即从噬菌体发育早期的指数双向模式转变为后期的非指数（滚环）模式。关于大多数复制分子的DNA复制不涉及这种机制变化的结论，是基于对感染后期特异性诱导的突变体克隆分布的分析得出的。在积累了100个噬菌体当量的DNA时，通过向感染细胞中添加5-溴脱氧尿苷诱导产生的突变体克隆分布，符合指数复制所预测的模式。
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