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来自噬菌体T4的复制DNA的结构

Structure of the replicating DNA from bacteriophage T4.

作者信息

Delius H, Howe C, Kozinski A W

出版信息

Proc Natl Acad Sci U S A. 1971 Dec;68(12):3049-53. doi: 10.1073/pnas.68.12.3049.

Abstract

At an early stage of replication, parental T4 DNA shows a loop structure often displaying two 3'-ended, single-stranded "whiskers", located in trans configuration at the branching-points. Several such loops have been observed within a single T4 molecule. Occasionally, reinitiation occurred in the middle of a loop, which suggests that the loop was growing in both directions.

摘要

在复制的早期阶段,亲代T4 DNA呈现出一种环状结构,常常显示出两个3'端的单链“须”,它们在分支点处以反式构型定位。在单个T4分子内已观察到几个这样的环。偶尔,重新起始会在环的中间发生,这表明环在两个方向上都在生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f44/389588/fffed54f75ce/pnas00087-0153-a.jpg

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