Xiang Xin
Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
J Cell Biol. 2003 Feb 3;160(3):289-90. doi: 10.1083/jcb.200212168.
The cytoplasmic dynein complex and its accessory dynactin complex are involved in many cellular activities including nuclear migration in fungi (for review see Karki and Holzbaur, 1999). LIS1, the product of a causal gene for human lissencephaly (smooth brain), has also been implicated in dynein function based on studies in fungi and more recent studies in higher eukaryotic systems (for review see Gupta et al., 2002). Exactly how LIS1 may regulate the behavior of cytoplasmic dynein in various organisms is a fascinating question. In this issue, Lee et al. (2003) describe important new findings in Saccharomyces cerevisiae regarding the role of LIS1 (Pac1) in dynein-mediated nuclear migration.
胞质动力蛋白复合体及其辅助动力蛋白激活复合体参与许多细胞活动，包括真菌中的核迁移（综述见Karki和Holzbaur，1999年）。LIS1是人类无脑回畸形（大脑平滑）致病基因的产物，基于真菌研究以及最近在高等真核生物系统中的研究，它也与动力蛋白功能有关（综述见Gupta等人，2002年）。LIS1究竟如何调控各种生物体中胞质动力蛋白的行为是一个引人入胜的问题。在本期中，Lee等人（2003年）描述了酿酒酵母中关于LIS1（Pac1）在动力蛋白介导的核迁移中的作用的重要新发现。
