Maurer-Stroh Sebastian, Dickens Nicholas J, Hughes-Davies Luke, Kouzarides Tony, Eisenhaber Frank, Ponting Chris P
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.
Trends Biochem Sci. 2003 Feb;28(2):69-74. doi: 10.1016/S0968-0004(03)00004-5.
We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.
我们已经鉴定出了一个“Agenet”结构域家族，它们是Tudor结构域的植物特异性同源物。利用序列依赖性和结构依赖性方法相结合，这一发现得到了扩展，结果表明Tudor、PWWP、染色质结合（Chromo）和MBT结构域的三个β链核心区域是同源的，因为它们起源于一个共同的祖先。此外，我们还揭示了脆性X智力低下蛋白（FMRP）家族中的串联重复序列对，它们也是这个Tudor结构域“王室家族”的成员。
