Beutler L E, Cano M C, Miró E, Buela-Casal G
University of California, Santa Barbara, USA.
J Clin Psychol. 2003 Mar;59(3):369-84. doi: 10.1002/jclp.10126.
The present investigation analyzes if the effect of Total Sleep Deprivation (TSD) on depressive mood in normal subjects is related to participants' activation levels. Reaction time (RT), subjective sleepiness, and depressive mood were assessed among 48 normal subjects who were subjected to 60 h of TSD. Subjects were divided into groups based on his/her depressive mood changes following TSD: subjects with worse response (n = 11), subjects with better response (n = 12), and intermediate group (n = 25). We sought to determine if RT and subjective sleepiness were related systematically to depressive mood changes following TSD. TSD produces a general reduction in activation (i.e., a monotonic increase in RT and subjective sleepiness) modulated by circadian oscillations. Baseline activation (RT) was confirmed partially as a predictor of participants' response to TSD. Subjects with high levels of activation (lower RTs at the baseline) experienced a better response (greater reductions in depressive mood) following TSD. There was no relationship between pre-treatment subjective sleepiness levels and the TSD effect on depressive mood. The results partially support the role of the activation level as a differential moderator of TSD effects on depressive mood in normal subjects.
本研究分析了完全睡眠剥夺（TSD）对正常受试者抑郁情绪的影响是否与参与者的激活水平有关。在48名经历了60小时TSD的正常受试者中评估了反应时间（RT）、主观嗜睡程度和抑郁情绪。根据TSD后受试者的抑郁情绪变化将其分为几组：反应较差的受试者（n = 11）、反应较好的受试者（n = 12）和中间组（n = 25）。我们试图确定RT和主观嗜睡程度是否与TSD后抑郁情绪的变化有系统关联。TSD会导致激活水平普遍降低（即RT和主观嗜睡程度单调增加），且受昼夜节律振荡调节。基线激活水平（RT）被部分证实可作为参与者对TSD反应的预测指标。激活水平高的受试者（基线时RT较低）在TSD后反应较好（抑郁情绪降低幅度更大）。治疗前主观嗜睡程度与TSD对抑郁情绪的影响之间没有关系。结果部分支持了激活水平作为TSD对正常受试者抑郁情绪影响的差异调节因素的作用。
